Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL)
Tingxue Zhang,1,2 Yilin Hou,1,2 Min Liu,2 Xiaoyu Hou,1,2 Yong Tang,2 Luping Ren,2 Guangyao Song1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of Chi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/correlation-between-the-levels-of-angptl3-angptl4-angptl8-and-postpran-peer-reviewed-fulltext-article-DMSO |
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| author | Zhang T Hou Y Liu M Hou X Tang Y Ren L Song G |
| author_facet | Zhang T Hou Y Liu M Hou X Tang Y Ren L Song G |
| author_sort | Zhang T |
| collection | DOAJ |
| description | Tingxue Zhang,1,2 Yilin Hou,1,2 Min Liu,2 Xiaoyu Hou,1,2 Yong Tang,2 Luping Ren,2 Guangyao Song1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of ChinaCorrespondence: Guangyao Song, Tel +86-0311-8598-8556, Email sguangyao2@163.comPurpose: To investigate the effects of different angiopoietin-like proteins (ANGPTLs) on postprandial hypertriglyceridemia (PPT) by analyzing changes in serum lipid, ANGPTL3, ANGPTL4, and ANGPTL8 levels before and after a high-fat diet in individuals with normal fasting lipid and oral glucose tolerance test results.Patients and Methods: Exactly 103 volunteers were recruited for an oral fat tolerance test (OFTT). Blood samples were obtained at 0, 2, and 4 h after eating to detect relevant indicators. PPT was defined as triglyceride (TG) levels ≥ 2.5 mmol/L. According to the test results, the participants were divided into two groups: postprandial normal triglycerides (PNT) and PPT. The levels of blood lipids and ANGPTL3, ANGPTL4, and ANGPTL8 were compared between the two groups.Results: There were differences in the body mass index (BMI), waist circumference (WC), fasting total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), triglyceride-rich lipoprotein cholesterol (TRL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB), ApoA1/ApoB, fasting blood glucose (FBG), fasting insulin (FINS), ANGPTL4, and ANGPTL8 between the two groups. In the PNT group, the TG level increased from baseline at 2 and 4 h, TRL-C increased from baseline at 4 h, and ANGPTL8 decreased from baseline at 2 and 4 h. After OFTT, the levels of TG, TRL-C, ANGPTL3, and ANGPTL4 in the PPT group gradually increased; ANGPTL8 gradually decreased. Fasting ANGPTL3 was positively associated with age, TC, HDL-C, TRL-C, and ApoA1, and negatively associated with systolic blood pressure. Fasting ANGPTL4 was positively correlated with weight, WC, BMI, TC, TG, LDL-C, TRL-C, non-HDL-C, ApoB, FBG, and FINS, and negatively correlated with ApoA1/ApoB and fasting ANGPTL8. Binary logistic regression analysis indicated that ANGPTL4 and ANGPTL8 were significant predictors of PPT.Conclusion: PPT occurrence is closely associated with changes in ANGPTL4 and ANGPTL8 levels.Keywords: dyslipidemia, serum lipid, ANGPTL proteins, oral fat tolerance test, postprandial normal triglyceride |
| first_indexed | 2024-03-09T02:45:21Z |
| format | Article |
| id | doaj.art-6c881a1e06944a5d958da60a4146ee1e |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-09T02:45:21Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-6c881a1e06944a5d958da60a4146ee1e2023-12-05T17:06:55ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-12-01Volume 163979399388773Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL)Zhang THou YLiu MHou XTang YRen LSong GTingxue Zhang,1,2 Yilin Hou,1,2 Min Liu,2 Xiaoyu Hou,1,2 Yong Tang,2 Luping Ren,2 Guangyao Song1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of ChinaCorrespondence: Guangyao Song, Tel +86-0311-8598-8556, Email sguangyao2@163.comPurpose: To investigate the effects of different angiopoietin-like proteins (ANGPTLs) on postprandial hypertriglyceridemia (PPT) by analyzing changes in serum lipid, ANGPTL3, ANGPTL4, and ANGPTL8 levels before and after a high-fat diet in individuals with normal fasting lipid and oral glucose tolerance test results.Patients and Methods: Exactly 103 volunteers were recruited for an oral fat tolerance test (OFTT). Blood samples were obtained at 0, 2, and 4 h after eating to detect relevant indicators. PPT was defined as triglyceride (TG) levels ≥ 2.5 mmol/L. According to the test results, the participants were divided into two groups: postprandial normal triglycerides (PNT) and PPT. The levels of blood lipids and ANGPTL3, ANGPTL4, and ANGPTL8 were compared between the two groups.Results: There were differences in the body mass index (BMI), waist circumference (WC), fasting total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), triglyceride-rich lipoprotein cholesterol (TRL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB), ApoA1/ApoB, fasting blood glucose (FBG), fasting insulin (FINS), ANGPTL4, and ANGPTL8 between the two groups. In the PNT group, the TG level increased from baseline at 2 and 4 h, TRL-C increased from baseline at 4 h, and ANGPTL8 decreased from baseline at 2 and 4 h. After OFTT, the levels of TG, TRL-C, ANGPTL3, and ANGPTL4 in the PPT group gradually increased; ANGPTL8 gradually decreased. Fasting ANGPTL3 was positively associated with age, TC, HDL-C, TRL-C, and ApoA1, and negatively associated with systolic blood pressure. Fasting ANGPTL4 was positively correlated with weight, WC, BMI, TC, TG, LDL-C, TRL-C, non-HDL-C, ApoB, FBG, and FINS, and negatively correlated with ApoA1/ApoB and fasting ANGPTL8. Binary logistic regression analysis indicated that ANGPTL4 and ANGPTL8 were significant predictors of PPT.Conclusion: PPT occurrence is closely associated with changes in ANGPTL4 and ANGPTL8 levels.Keywords: dyslipidemia, serum lipid, ANGPTL proteins, oral fat tolerance test, postprandial normal triglyceridehttps://www.dovepress.com/correlation-between-the-levels-of-angptl3-angptl4-angptl8-and-postpran-peer-reviewed-fulltext-article-DMSOdyslipidemiaserum lipidangptl proteinsoral fat tolerance testpostprandial normal triglyceride |
| spellingShingle | Zhang T Hou Y Liu M Hou X Tang Y Ren L Song G Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL) Diabetes, Metabolic Syndrome and Obesity dyslipidemia serum lipid angptl proteins oral fat tolerance test postprandial normal triglyceride |
| title | Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL) |
| title_full | Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL) |
| title_fullStr | Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL) |
| title_full_unstemmed | Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL) |
| title_short | Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL) |
| title_sort | correlation between the levels of angptl3 angptl4 angptl8 and postprandial triglyceride rich lipoprotein trl |
| topic | dyslipidemia serum lipid angptl proteins oral fat tolerance test postprandial normal triglyceride |
| url | https://www.dovepress.com/correlation-between-the-levels-of-angptl3-angptl4-angptl8-and-postpran-peer-reviewed-fulltext-article-DMSO |
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