Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma
A 4 cm diameter exophytic mass was excised from the left flank of a 10-year-old domestic short-haired cat. Histology of the superficial aspects of the mass revealed epidermal cells arranged in nests and trabeculae while the deeper parts of the mass consisted of small round cells arranged in sheets o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/12/671 |
| _version_ | 1797454970540261376 |
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| author | John S. Munday Hayley Hunt Geoff Orbell Hayley Pfeffer |
| author_facet | John S. Munday Hayley Hunt Geoff Orbell Hayley Pfeffer |
| author_sort | John S. Munday |
| collection | DOAJ |
| description | A 4 cm diameter exophytic mass was excised from the left flank of a 10-year-old domestic short-haired cat. Histology of the superficial aspects of the mass revealed epidermal cells arranged in nests and trabeculae while the deeper parts of the mass consisted of small round cells arranged in sheets or bundles of elongate spindle-shaped cells. A diagnosis of basal cell carcinoma (BCC) was made. Approximately 40% of the cells throughout the neoplasm contained prominent papillomaviral (PV)-induced cell changes. The BCC recurred three months after excision and grew rapidly. At this time a smaller mass was observed on the thorax. Due to the rapid recurrence of the BCC, the cat was euthanatized. As in the initial mass, histology of the recurrent mass revealed pleomorphic cells that often contained PV-induced cell changes. In contrast, the thoracic mass appeared as a more typical BCC and contained no histological evidence of PV infection. A novel PV DNA sequence was amplified from the flank BCC. While the sequence was most (75.1%) similar to Felis catus papillomavirus (FcaPV) 6, the level of similarity between the sequences is consistent with a novel PV type. No PV DNA was amplifiable from the thoracic mass. The case is unique due to the histological features of the BCC and the presence of a putative novel PV type. Observations from the present case add to the number of PV types associated with disease in cats as well as increasing the spectrum of PV-induced lesions in this species. |
| first_indexed | 2024-03-09T15:45:48Z |
| format | Article |
| id | doaj.art-6c8ab20be8a14ea88bbd01f88b9b9a24 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T15:45:48Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-6c8ab20be8a14ea88bbd01f88b9b9a242023-11-24T18:35:06ZengMDPI AGVeterinary Sciences2306-73812022-12-0191267110.3390/vetsci9120671Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell CarcinomaJohn S. Munday0Hayley Hunt1Geoff Orbell2Hayley Pfeffer3School of Veterinary Science, Massey University, Palmerston North 4410, New ZealandSchool of Veterinary Science, Massey University, Palmerston North 4410, New ZealandGribbles Veterinary Pathology Ltd., Palmerston North 4410, New ZealandVetora, Te Awamutu 3800, New ZealandA 4 cm diameter exophytic mass was excised from the left flank of a 10-year-old domestic short-haired cat. Histology of the superficial aspects of the mass revealed epidermal cells arranged in nests and trabeculae while the deeper parts of the mass consisted of small round cells arranged in sheets or bundles of elongate spindle-shaped cells. A diagnosis of basal cell carcinoma (BCC) was made. Approximately 40% of the cells throughout the neoplasm contained prominent papillomaviral (PV)-induced cell changes. The BCC recurred three months after excision and grew rapidly. At this time a smaller mass was observed on the thorax. Due to the rapid recurrence of the BCC, the cat was euthanatized. As in the initial mass, histology of the recurrent mass revealed pleomorphic cells that often contained PV-induced cell changes. In contrast, the thoracic mass appeared as a more typical BCC and contained no histological evidence of PV infection. A novel PV DNA sequence was amplified from the flank BCC. While the sequence was most (75.1%) similar to Felis catus papillomavirus (FcaPV) 6, the level of similarity between the sequences is consistent with a novel PV type. No PV DNA was amplifiable from the thoracic mass. The case is unique due to the histological features of the BCC and the presence of a putative novel PV type. Observations from the present case add to the number of PV types associated with disease in cats as well as increasing the spectrum of PV-induced lesions in this species.https://www.mdpi.com/2306-7381/9/12/671catpapillomavirusneoplasiacancerbasal cell carcinomaskin |
| spellingShingle | John S. Munday Hayley Hunt Geoff Orbell Hayley Pfeffer Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma Veterinary Sciences cat papillomavirus neoplasia cancer basal cell carcinoma skin |
| title | Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma |
| title_full | Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma |
| title_fullStr | Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma |
| title_full_unstemmed | Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma |
| title_short | Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma |
| title_sort | detection of a novel papillomavirus type within a feline cutaneous basal cell carcinoma |
| topic | cat papillomavirus neoplasia cancer basal cell carcinoma skin |
| url | https://www.mdpi.com/2306-7381/9/12/671 |
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