Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011
<span lang="EN-US">The present study aimed to evaluate the evolution of antibiotic resistance in clinical isolates of <em>Klebsiella pneumonia</em>e in the period of 2000 to 2011, at the University Hospital of Londrina (HU-UEL). A retrospective analysis of 2,318 antimicro...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Estadual de Londrina
2015-05-01
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| Series: | Semina: Ciências Biológicas e da Saúde |
| Subjects: | |
| Online Access: | http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19397 |
| Summary: | <span lang="EN-US">The present study aimed to evaluate the evolution of antibiotic resistance in clinical isolates of <em>Klebsiella pneumonia</em>e in the period of 2000 to 2011, at the University Hospital of Londrina (HU-UEL). A retrospective analysis of 2,318 antimicrobial susceptibility tests of <em>K. pneumoniae</em> was performed from a database of the Clinical Laboratory of Microbiology of the University Hospital. In the period of 2000 to 2009, the main mechanism of resistance observed to ?-lactam antimicrobials was due to the production of ESBL ?-lactamase type (?-lactamase wide spectrum), which can be verified by the increased resistance of <em>K. pneumoniae</em> to 3rd generation cephalosporins and cefepime. However, the first strains of <em>K. pneumoniae</em> carbapenemase-producing appeared in 2009, compromising the efficacy of carbapenems. The rates of resistance to ertapenem ranged from 16%, in 2005, to 40% in 2011. Another class of committed antibiotics was the fluoroquinolones; for ciprofloxacin, resistance rates ranged from 13% to 62%, in 2001 and 2011, </span>respectively. Aminoglycosides exhibited oscillations of resistance during the period studied, reaching, in 2011, values of 56% and 30% for gentamicin and amikacin, respectively. Meanwhile, trimethoprim/ sulfamethoxazole and piperacillin/tazobactam reached about 60%, in the same period. Therefore, knowing the antimicrobial resistance of <em>K. pneumoniae</em> strains is essential for proper treatment of patients and adoption of appropriate measures that aims infection control, and proper use of these drugs. |
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| ISSN: | 1676-5435 1679-0367 |