Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011
<span lang="EN-US">The present study aimed to evaluate the evolution of antibiotic resistance in clinical isolates of <em>Klebsiella pneumonia</em>e in the period of 2000 to 2011, at the University Hospital of Londrina (HU-UEL). A retrospective analysis of 2,318 antimicro...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Estadual de Londrina
2015-05-01
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| Series: | Semina: Ciências Biológicas e da Saúde |
| Subjects: | |
| Online Access: | http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19397 |
| _version_ | 1811228193558888448 |
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| author | Diogo Jorge Rossi Daniele Zendrini Rechenchoski Ana Carolina Polano Vivan Angélica Marim Lopes Dambrozio Renata Perugini Biasi Garbin Gerusa Luciana Gomes Magalhães Regina Mariuza Borsato Quesada Floristher Elaine Carrara Marroni Marsileni Pelisson Marcia Regina Eches Perugini Eliana Carolina Vespero |
| author_facet | Diogo Jorge Rossi Daniele Zendrini Rechenchoski Ana Carolina Polano Vivan Angélica Marim Lopes Dambrozio Renata Perugini Biasi Garbin Gerusa Luciana Gomes Magalhães Regina Mariuza Borsato Quesada Floristher Elaine Carrara Marroni Marsileni Pelisson Marcia Regina Eches Perugini Eliana Carolina Vespero |
| author_sort | Diogo Jorge Rossi |
| collection | DOAJ |
| description | <span lang="EN-US">The present study aimed to evaluate the evolution of antibiotic resistance in clinical isolates of <em>Klebsiella pneumonia</em>e in the period of 2000 to 2011, at the University Hospital of Londrina (HU-UEL). A retrospective analysis of 2,318 antimicrobial susceptibility tests of <em>K. pneumoniae</em> was performed from a database of the Clinical Laboratory of Microbiology of the University Hospital. In the period of 2000 to 2009, the main mechanism of resistance observed to ?-lactam antimicrobials was due to the production of ESBL ?-lactamase type (?-lactamase wide spectrum), which can be verified by the increased resistance of <em>K. pneumoniae</em> to 3rd generation cephalosporins and cefepime. However, the first strains of <em>K. pneumoniae</em> carbapenemase-producing appeared in 2009, compromising the efficacy of carbapenems. The rates of resistance to ertapenem ranged from 16%, in 2005, to 40% in 2011. Another class of committed antibiotics was the fluoroquinolones; for ciprofloxacin, resistance rates ranged from 13% to 62%, in 2001 and 2011, </span>respectively. Aminoglycosides exhibited oscillations of resistance during the period studied, reaching, in 2011, values of 56% and 30% for gentamicin and amikacin, respectively. Meanwhile, trimethoprim/ sulfamethoxazole and piperacillin/tazobactam reached about 60%, in the same period. Therefore, knowing the antimicrobial resistance of <em>K. pneumoniae</em> strains is essential for proper treatment of patients and adoption of appropriate measures that aims infection control, and proper use of these drugs. |
| first_indexed | 2024-04-12T09:54:10Z |
| format | Article |
| id | doaj.art-6c8cc45b6dfd4fe18c7599b2d08857da |
| institution | Directory Open Access Journal |
| issn | 1676-5435 1679-0367 |
| language | English |
| last_indexed | 2024-04-12T09:54:10Z |
| publishDate | 2015-05-01 |
| publisher | Universidade Estadual de Londrina |
| record_format | Article |
| series | Semina: Ciências Biológicas e da Saúde |
| spelling | doaj.art-6c8cc45b6dfd4fe18c7599b2d08857da2022-12-22T03:37:45ZengUniversidade Estadual de LondrinaSemina: Ciências Biológicas e da Saúde1676-54351679-03672015-05-01361Supl26727410.5433/1679-0367.2015v36n1Suplp26711806Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011Diogo Jorge Rossi0Daniele Zendrini Rechenchoski1Ana Carolina Polano Vivan2Angélica Marim Lopes Dambrozio3Renata Perugini Biasi Garbin4Gerusa Luciana Gomes Magalhães5Regina Mariuza Borsato Quesada6Floristher Elaine Carrara Marroni7Marsileni Pelisson8Marcia Regina Eches Perugini9Eliana Carolina Vespero10Universidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade de São PauloUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UELUniversidade Estadual de Londrina - UEL<span lang="EN-US">The present study aimed to evaluate the evolution of antibiotic resistance in clinical isolates of <em>Klebsiella pneumonia</em>e in the period of 2000 to 2011, at the University Hospital of Londrina (HU-UEL). A retrospective analysis of 2,318 antimicrobial susceptibility tests of <em>K. pneumoniae</em> was performed from a database of the Clinical Laboratory of Microbiology of the University Hospital. In the period of 2000 to 2009, the main mechanism of resistance observed to ?-lactam antimicrobials was due to the production of ESBL ?-lactamase type (?-lactamase wide spectrum), which can be verified by the increased resistance of <em>K. pneumoniae</em> to 3rd generation cephalosporins and cefepime. However, the first strains of <em>K. pneumoniae</em> carbapenemase-producing appeared in 2009, compromising the efficacy of carbapenems. The rates of resistance to ertapenem ranged from 16%, in 2005, to 40% in 2011. Another class of committed antibiotics was the fluoroquinolones; for ciprofloxacin, resistance rates ranged from 13% to 62%, in 2001 and 2011, </span>respectively. Aminoglycosides exhibited oscillations of resistance during the period studied, reaching, in 2011, values of 56% and 30% for gentamicin and amikacin, respectively. Meanwhile, trimethoprim/ sulfamethoxazole and piperacillin/tazobactam reached about 60%, in the same period. Therefore, knowing the antimicrobial resistance of <em>K. pneumoniae</em> strains is essential for proper treatment of patients and adoption of appropriate measures that aims infection control, and proper use of these drugs.http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19397Klebsiella pneumoniaeESBLKPCResistência antimicrobiana. |
| spellingShingle | Diogo Jorge Rossi Daniele Zendrini Rechenchoski Ana Carolina Polano Vivan Angélica Marim Lopes Dambrozio Renata Perugini Biasi Garbin Gerusa Luciana Gomes Magalhães Regina Mariuza Borsato Quesada Floristher Elaine Carrara Marroni Marsileni Pelisson Marcia Regina Eches Perugini Eliana Carolina Vespero Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011 Semina: Ciências Biológicas e da Saúde Klebsiella pneumoniae ESBL KPC Resistência antimicrobiana. |
| title | Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011 |
| title_full | Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011 |
| title_fullStr | Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011 |
| title_full_unstemmed | Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011 |
| title_short | Evolution of resistance of Klebsiella pneumoniae in Londrina University Hospital from 2000 to 2011 |
| title_sort | evolution of resistance of klebsiella pneumoniae in londrina university hospital from 2000 to 2011 |
| topic | Klebsiella pneumoniae ESBL KPC Resistência antimicrobiana. |
| url | http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19397 |
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