The Role of Osteopontin in Respiratory Health and Disease
The biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone disease. We aimed to present the role of OPN in resp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/8/1259 |
| _version_ | 1797584186662453248 |
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| author | Georgios I. Barkas Ourania S. Kotsiou |
| author_facet | Georgios I. Barkas Ourania S. Kotsiou |
| author_sort | Georgios I. Barkas |
| collection | DOAJ |
| description | The biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone disease. We aimed to present the role of OPN in respiratory health and disease. OPN influences the immune system and is a chemo-attractive protein correlated with respiratory disease severity. There is evidence that OPN can advance the disease stage associated with its fibrotic, inflammatory, and immune functions. OPN contributes to eosinophilic airway inflammation. OPN can destroy the lung parenchyma through its neutrophil influx and fibrotic mechanisms, linking OPN to at least one of the two major chronic obstructive pulmonary disease phenotypes. Respiratory diseases that involve irreversible lung scarring, such as idiopathic pulmonary disease, are linked to OPN, with protein levels being overexpressed in individuals with severe or advanced stages of the disorders and considerably lower levels in those with less severe symptoms. OPN plays a significant role in lung cancer progression and metastasis. It is also implicated in the pathogenesis of pulmonary hypertension, coronavirus disease 2019, and granuloma generation. |
| first_indexed | 2024-03-10T23:48:31Z |
| format | Article |
| id | doaj.art-6c8d665f9e624abfaac3c131fa5cb5fc |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T23:48:31Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-6c8d665f9e624abfaac3c131fa5cb5fc2023-11-19T01:49:25ZengMDPI AGJournal of Personalized Medicine2075-44262023-08-01138125910.3390/jpm13081259The Role of Osteopontin in Respiratory Health and DiseaseGeorgios I. Barkas0Ourania S. Kotsiou1Department of Human Pathophysiology, Faculty of Nursing, University of Thessaly, 41500 Larissa, GreeceDepartment of Human Pathophysiology, Faculty of Nursing, University of Thessaly, 41500 Larissa, GreeceThe biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone disease. We aimed to present the role of OPN in respiratory health and disease. OPN influences the immune system and is a chemo-attractive protein correlated with respiratory disease severity. There is evidence that OPN can advance the disease stage associated with its fibrotic, inflammatory, and immune functions. OPN contributes to eosinophilic airway inflammation. OPN can destroy the lung parenchyma through its neutrophil influx and fibrotic mechanisms, linking OPN to at least one of the two major chronic obstructive pulmonary disease phenotypes. Respiratory diseases that involve irreversible lung scarring, such as idiopathic pulmonary disease, are linked to OPN, with protein levels being overexpressed in individuals with severe or advanced stages of the disorders and considerably lower levels in those with less severe symptoms. OPN plays a significant role in lung cancer progression and metastasis. It is also implicated in the pathogenesis of pulmonary hypertension, coronavirus disease 2019, and granuloma generation.https://www.mdpi.com/2075-4426/13/8/1259respiratory diseaseosteopontininflammationcancer |
| spellingShingle | Georgios I. Barkas Ourania S. Kotsiou The Role of Osteopontin in Respiratory Health and Disease Journal of Personalized Medicine respiratory disease osteopontin inflammation cancer |
| title | The Role of Osteopontin in Respiratory Health and Disease |
| title_full | The Role of Osteopontin in Respiratory Health and Disease |
| title_fullStr | The Role of Osteopontin in Respiratory Health and Disease |
| title_full_unstemmed | The Role of Osteopontin in Respiratory Health and Disease |
| title_short | The Role of Osteopontin in Respiratory Health and Disease |
| title_sort | role of osteopontin in respiratory health and disease |
| topic | respiratory disease osteopontin inflammation cancer |
| url | https://www.mdpi.com/2075-4426/13/8/1259 |
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