Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis
Cerebrospinal fluid levels of tumor necrosis factor-alpha and interleukin-1 beta in 78 children with nonbacterial, bacterial and tuberculous meningitis, and in 34 control subjects were analyzed in order to evaluate the involvement of these cytokines in the pathogenesis of acute bacterial meni...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
1997-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3386 |
| _version_ | 1826543669405024256 |
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| author | M Ceyhan G Kanra Z Ecevit G Seçmeer G Erdem O Akan O Müftüoğlu |
| author_facet | M Ceyhan G Kanra Z Ecevit G Seçmeer G Erdem O Akan O Müftüoğlu |
| author_sort | M Ceyhan |
| collection | DOAJ |
| description |
Cerebrospinal fluid levels of tumor necrosis factor-alpha and interleukin-1 beta in 78 children with nonbacterial, bacterial and tuberculous meningitis, and in 34 control subjects were analyzed in order to evaluate the involvement of these cytokines in the pathogenesis of acute bacterial meningitis and their discriminative value between different etiologies of meningitis. Tumor necrosis factor-alpha and interleukin-1 beta levels were significantly higher in bacterial and tuberculous meningitis than in aseptic meningitis and in control subjects (p < 0.0001). There was no difference in the levels of tumor necrosis factor-alpha and interleukin-1 beta between nonbacterial meningitis and control groups. The finding that both tumor necrosis factor-alpha and interleukin-1 beta are increased in the cerebrospinal fluid of patients with bacterial and tuberculous meningitis whereas normal levels of these two cytokines have been found in patients with nonbacterial meningitis signifies that these cytokines may be used to differentiate between bacterial and nonbacterial meningitis.
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| first_indexed | 2025-03-14T04:49:45Z |
| format | Article |
| id | doaj.art-6c8eed2474064ccca7717f56976266e9 |
| institution | Directory Open Access Journal |
| issn | 0041-4301 2791-6421 |
| language | English |
| last_indexed | 2025-03-14T04:49:45Z |
| publishDate | 1997-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj.art-6c8eed2474064ccca7717f56976266e92025-03-07T19:44:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211997-04-01392Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitisM Ceyhan0G KanraZ EcevitG SeçmeerG ErdemO AkanO MüftüoğluDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara. Cerebrospinal fluid levels of tumor necrosis factor-alpha and interleukin-1 beta in 78 children with nonbacterial, bacterial and tuberculous meningitis, and in 34 control subjects were analyzed in order to evaluate the involvement of these cytokines in the pathogenesis of acute bacterial meningitis and their discriminative value between different etiologies of meningitis. Tumor necrosis factor-alpha and interleukin-1 beta levels were significantly higher in bacterial and tuberculous meningitis than in aseptic meningitis and in control subjects (p < 0.0001). There was no difference in the levels of tumor necrosis factor-alpha and interleukin-1 beta between nonbacterial meningitis and control groups. The finding that both tumor necrosis factor-alpha and interleukin-1 beta are increased in the cerebrospinal fluid of patients with bacterial and tuberculous meningitis whereas normal levels of these two cytokines have been found in patients with nonbacterial meningitis signifies that these cytokines may be used to differentiate between bacterial and nonbacterial meningitis. https://turkjpediatr.org/article/view/3386 |
| spellingShingle | M Ceyhan G Kanra Z Ecevit G Seçmeer G Erdem O Akan O Müftüoğlu Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis The Turkish Journal of Pediatrics |
| title | Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis |
| title_full | Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis |
| title_fullStr | Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis |
| title_full_unstemmed | Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis |
| title_short | Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis |
| title_sort | tumor necrosis factor alpha and interleukin 1 beta levels in children with bacterial tuberculous and aseptic meningitis |
| url | https://turkjpediatr.org/article/view/3386 |
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