FGFR2–BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model

FGFR2–BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model

Epigenetic reprogramming is an independent mode of gene expression that often involves changes in the transcription and chromatin structure due to tumor initiation and development. In this study, we developed a specifically modified peptide array and searched for a recognized epigenetic reader. Our...

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Bibliographic Details
Main Authors: Josh Haipeng Lei, Lei Zhang, Zhenyi Wang, Raoul Peltier, Yusheng Xie, Ganchao Chen, Shiqi Lin, Kai Miao, Chu-Xia Deng, Hongyan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
epigenetic
BRD4
FGFR2
TNBC
posttranslational modifications
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.861221/full

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