IL-1 Family Antagonists in Mouse and Human Skin Inflammation
Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammatory diseases. Dysregulated IL-1 family signaling is observed in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.652846/full |
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| author | Praxedis Martin Praxedis Martin Jérémie D. Goldstein Jérémie D. Goldstein Loïc Mermoud Loïc Mermoud Alejandro Diaz-Barreiro Alejandro Diaz-Barreiro Gaby Palmer Gaby Palmer |
| author_facet | Praxedis Martin Praxedis Martin Jérémie D. Goldstein Jérémie D. Goldstein Loïc Mermoud Loïc Mermoud Alejandro Diaz-Barreiro Alejandro Diaz-Barreiro Gaby Palmer Gaby Palmer |
| author_sort | Praxedis Martin |
| collection | DOAJ |
| description | Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammatory diseases. Dysregulated IL-1 family signaling is observed in a variety of skin disorders. In particular, IL-1 family cytokines have been linked to the pathogenesis of psoriasis and atopic dermatitis. The biological activity of pro-inflammatory IL-1 family agonists is controlled by the natural receptor antagonists IL-1Ra and IL-36Ra, as well as by the regulatory cytokines IL-37 and IL-38. These four anti-inflammatory IL-1 family members are constitutively and highly expressed at steady state in the epidermis, where keratinocytes are a major producing cell type. In this review, we provide an overview of the current knowledge concerning their regulatory roles in skin biology and inflammation and their therapeutic potential in human inflammatory skin diseases. We further highlight some common misunderstandings and less well-known observations, which persist in the field despite recent extensive interest for these cytokines. |
| first_indexed | 2024-12-16T20:34:17Z |
| format | Article |
| id | doaj.art-6c907043bc8f404bb183c0b05c09fdd8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T20:34:17Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6c907043bc8f404bb183c0b05c09fdd82022-12-21T22:17:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.652846652846IL-1 Family Antagonists in Mouse and Human Skin InflammationPraxedis Martin0Praxedis Martin1Jérémie D. Goldstein2Jérémie D. Goldstein3Loïc Mermoud4Loïc Mermoud5Alejandro Diaz-Barreiro6Alejandro Diaz-Barreiro7Gaby Palmer8Gaby Palmer9Division of Rheumatology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Rheumatology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Rheumatology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Rheumatology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Rheumatology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandInterleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammatory diseases. Dysregulated IL-1 family signaling is observed in a variety of skin disorders. In particular, IL-1 family cytokines have been linked to the pathogenesis of psoriasis and atopic dermatitis. The biological activity of pro-inflammatory IL-1 family agonists is controlled by the natural receptor antagonists IL-1Ra and IL-36Ra, as well as by the regulatory cytokines IL-37 and IL-38. These four anti-inflammatory IL-1 family members are constitutively and highly expressed at steady state in the epidermis, where keratinocytes are a major producing cell type. In this review, we provide an overview of the current knowledge concerning their regulatory roles in skin biology and inflammation and their therapeutic potential in human inflammatory skin diseases. We further highlight some common misunderstandings and less well-known observations, which persist in the field despite recent extensive interest for these cytokines.https://www.frontiersin.org/articles/10.3389/fimmu.2021.652846/fullatopic dermatitiscytokineinflammationinterleukin-1psoriasisskin |
| spellingShingle | Praxedis Martin Praxedis Martin Jérémie D. Goldstein Jérémie D. Goldstein Loïc Mermoud Loïc Mermoud Alejandro Diaz-Barreiro Alejandro Diaz-Barreiro Gaby Palmer Gaby Palmer IL-1 Family Antagonists in Mouse and Human Skin Inflammation Frontiers in Immunology atopic dermatitis cytokine inflammation interleukin-1 psoriasis skin |
| title | IL-1 Family Antagonists in Mouse and Human Skin Inflammation |
| title_full | IL-1 Family Antagonists in Mouse and Human Skin Inflammation |
| title_fullStr | IL-1 Family Antagonists in Mouse and Human Skin Inflammation |
| title_full_unstemmed | IL-1 Family Antagonists in Mouse and Human Skin Inflammation |
| title_short | IL-1 Family Antagonists in Mouse and Human Skin Inflammation |
| title_sort | il 1 family antagonists in mouse and human skin inflammation |
| topic | atopic dermatitis cytokine inflammation interleukin-1 psoriasis skin |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.652846/full |
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