The Linoleic Acid Content of the Stratum Corneum of Ichthyotic Golden Retriever Dogs Is Reduced as Compared to Healthy Dogs and a Significant Part Is Oxidized in Both Free and Esterified Forms

The Linoleic Acid Content of the Stratum Corneum of Ichthyotic Golden Retriever Dogs Is Reduced as Compared to Healthy Dogs and a Significant Part Is Oxidized in Both Free and Esterified Forms

Golden Retrievers may suffer from <i>Pnpl1</i>-related inherited ichthyosis. Our study shows that in the stratum corneum (SC) of ichthyotic dogs, linoleic acid (LA) is also present in the form of 9-keto-octadecadienoic acid (9-KODE) instead of the acylacid form as in normal dogs. The fat...

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Bibliographic Details
Main Authors: Iuliana Popa, Audrey Solgadi, Didier Pin, Adrian L. Watson, Marek Haftek, Jacques Portoukalian
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Metabolites
Subjects:
linoleic acid
stratum corneum
dogs
ichthyosis
hydroperoxide
Online Access:https://www.mdpi.com/2218-1989/11/12/803

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