Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study
Background: Many suspected laryngopharyngeal neoplasms are examination under general anaesthesia (EUA). Office-based endoscopy is already routinely performed on all patients presenting with a suspected laryngopharyngeal neoplasm. Accurate clinical staging and tissue sampling using flexible endoscopy...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AOSIS
2019-04-01
|
| Series: | South African Journal of Oncology |
| Subjects: | |
| Online Access: | https://sajo.org.za/index.php/sajo/article/view/56 |
| _version_ | 1828922210223390720 |
|---|---|
| author | Hendrik K. Uys Andrew Pelser Rory Attwood Shaun Adam Amir Afrogheh Jos Hille James W. Loock |
| author_facet | Hendrik K. Uys Andrew Pelser Rory Attwood Shaun Adam Amir Afrogheh Jos Hille James W. Loock |
| author_sort | Hendrik K. Uys |
| collection | DOAJ |
| description | Background: Many suspected laryngopharyngeal neoplasms are examination under general anaesthesia (EUA). Office-based endoscopy is already routinely performed on all patients presenting with a suspected laryngopharyngeal neoplasm. Accurate clinical staging and tissue sampling using flexible endoscopy may eliminate the need for EUA.
Aim: To compare the use of flexible endoscopy to EUA as primary diagnostic tool of laryngopharyngeal lesions to EUA, using accuracy of tissue samples obtained and clinical staging as primary outcome measures. Duration, patient tolerance and cost implications were also assessed.
Setting: The study was performed in the outpatient department and surgical theatres of Tygerberg Hospital, Cape Town, South Africa.
Methods: A prospective study compared staging and tissue sampling accuracy with flexible endoscopy to EUA in 54 patients. Duration, tolerance and cost implications were also assessed.
Results: Flexible endoscopic biopsy had a 77.1% sensitivity, 100% specificity and 82.2% diagnostic accuracy. Liquid-based cytology had 97.3% sensitivity, 100% specificity and 97.9% diagnostic accuracy in differentiating high-grade lesions from low-grade lesions. Local staging agreement occurred in 88.6% (n = 31/35) of malignant cases. The mean duration was 15 ± 7 min; 86% of patients perceived the procedure as tolerable. Flexible endoscopy as a primary diagnostic tool would have avoided EUA in 68.6% (n = 24/35) of squamous cell carcinoma cases, with a R128 232 cost savings.
Conclusion: Office-based endoscopy is an accurate, well-tolerated, time- and cost-effective primary diagnostic tool of laryngopharyngeal lesions. It reduces the number of patients requiring EUA. Further evaluation is empirical when the histopathology does not confirm the clinical suspicion of malignancy. |
| first_indexed | 2024-12-13T22:16:33Z |
| format | Article |
| id | doaj.art-6c93c7a2c4d34ef1ade563d0f16ae88f |
| institution | Directory Open Access Journal |
| issn | 2518-8704 2523-0646 |
| language | English |
| last_indexed | 2024-12-13T22:16:33Z |
| publishDate | 2019-04-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Oncology |
| spelling | doaj.art-6c93c7a2c4d34ef1ade563d0f16ae88f2022-12-21T23:29:31ZengAOSISSouth African Journal of Oncology2518-87042523-06462019-04-0130e1e810.4102/sajo.v3i0.5633Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective studyHendrik K. Uys0Andrew Pelser1Rory Attwood2Shaun Adam3Amir Afrogheh4Jos Hille5James W. Loock6Department of Otolaryngology, Stellenbosch University, Cape TownDepartment of Otolaryngology, Stellenbosch University, Cape TownDepartment of Otolaryngology, Stellenbosch University, Cape TownDepartment of Otolaryngology, Stellenbosch University, Cape TownDepartment of Oral and Maxillofacial Pathology, Stellenbosch University, Cape Town, South Africa; and, National Health Laboratory Services of South Africa, JohannesburgDepartment of Oral and Maxillofacial Pathology, University of the Western Cape, Cape Town, South Africa; and, National Health Laboratory Services of South Africa, JohannesburgDepartment of Otolaryngology, Stellenbosch University, Cape TownBackground: Many suspected laryngopharyngeal neoplasms are examination under general anaesthesia (EUA). Office-based endoscopy is already routinely performed on all patients presenting with a suspected laryngopharyngeal neoplasm. Accurate clinical staging and tissue sampling using flexible endoscopy may eliminate the need for EUA. Aim: To compare the use of flexible endoscopy to EUA as primary diagnostic tool of laryngopharyngeal lesions to EUA, using accuracy of tissue samples obtained and clinical staging as primary outcome measures. Duration, patient tolerance and cost implications were also assessed. Setting: The study was performed in the outpatient department and surgical theatres of Tygerberg Hospital, Cape Town, South Africa. Methods: A prospective study compared staging and tissue sampling accuracy with flexible endoscopy to EUA in 54 patients. Duration, tolerance and cost implications were also assessed. Results: Flexible endoscopic biopsy had a 77.1% sensitivity, 100% specificity and 82.2% diagnostic accuracy. Liquid-based cytology had 97.3% sensitivity, 100% specificity and 97.9% diagnostic accuracy in differentiating high-grade lesions from low-grade lesions. Local staging agreement occurred in 88.6% (n = 31/35) of malignant cases. The mean duration was 15 ± 7 min; 86% of patients perceived the procedure as tolerable. Flexible endoscopy as a primary diagnostic tool would have avoided EUA in 68.6% (n = 24/35) of squamous cell carcinoma cases, with a R128 232 cost savings. Conclusion: Office-based endoscopy is an accurate, well-tolerated, time- and cost-effective primary diagnostic tool of laryngopharyngeal lesions. It reduces the number of patients requiring EUA. Further evaluation is empirical when the histopathology does not confirm the clinical suspicion of malignancy.https://sajo.org.za/index.php/sajo/article/view/56office-based procedureflexible endoscopybiopsystaginglarynxpharynx |
| spellingShingle | Hendrik K. Uys Andrew Pelser Rory Attwood Shaun Adam Amir Afrogheh Jos Hille James W. Loock Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study South African Journal of Oncology office-based procedure flexible endoscopy biopsy staging larynx pharynx |
| title | Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study |
| title_full | Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study |
| title_fullStr | Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study |
| title_full_unstemmed | Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study |
| title_short | Diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy: A prospective study |
| title_sort | diagnosis and staging of laryngopharyngeal tumours with flexible endoscopy a prospective study |
| topic | office-based procedure flexible endoscopy biopsy staging larynx pharynx |
| url | https://sajo.org.za/index.php/sajo/article/view/56 |
| work_keys_str_mv | AT hendrikkuys diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy AT andrewpelser diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy AT roryattwood diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy AT shaunadam diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy AT amirafrogheh diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy AT joshille diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy AT jameswloock diagnosisandstagingoflaryngopharyngealtumourswithflexibleendoscopyaprospectivestudy |