THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL
Aim. To assess the association of efficacy and safety endpoints with simultaneous carriage of polymorphic variants of the gene CYP2C19: rs4244285 (*2), and rs12248560 (*17) in treatment with clopidogrel.Material and methods. In the study, 289 patients included, from large cities of Siberia, underwen...
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«FIRMA «SILICEA» LLC
2017-11-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2522 |
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| author | Е. М. Zelenskaya О. L. Barbarash V. I. Ganyukov N. A. Kochergin К. A. Apartsin А. V. Gorokhova S. А. Papeshina К. Yu. Nikolaev К. Yu. Batueva S. V. Yankovskaya А. V. Tronin G. I. Lifshits |
| author_facet | Е. М. Zelenskaya О. L. Barbarash V. I. Ganyukov N. A. Kochergin К. A. Apartsin А. V. Gorokhova S. А. Papeshina К. Yu. Nikolaev К. Yu. Batueva S. V. Yankovskaya А. V. Tronin G. I. Lifshits |
| author_sort | Е. М. Zelenskaya |
| collection | DOAJ |
| description | Aim. To assess the association of efficacy and safety endpoints with simultaneous carriage of polymorphic variants of the gene CYP2C19: rs4244285 (*2), and rs12248560 (*17) in treatment with clopidogrel.Material and methods. In the study, 289 patients included, from large cities of Siberia, underwent coronary stenting for acute coronary syndrome. All participants were assessed for alleles CYP2C19*2, *3, *17, and clinical outcomes were followed for 30 days (thrombotic complications, bleedings).Results. It was found that simultaneous carriage of CYP2C19*2 and CYP2C19*17 alleles is associated with the risk of serious adverse events development of thrombotic origin comparing to the absence of such polymorphism carriage (p=0,016), and with general adverse events risk related to insufficiency of clopidogrel action (р=0,046).Conclusion. According to the study results, subjects with the *2/*17 carriage should be classified to a delayed clopidogrel metabolism group, as in the group definite and probable stent thrombosis were found significantly more prevalent. |
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| issn | 1560-4071 2618-7620 |
| language | Russian |
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| publisher | «FIRMA «SILICEA» LLC |
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| spelling | doaj.art-6c95d5f9f5ff464fb60df04a018a9dc52025-03-02T11:42:43Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-11-0101011311710.15829/1560-4071-2017-10-113-1172249THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGRELЕ. М. Zelenskaya0О. L. Barbarash1V. I. Ganyukov2N. A. Kochergin3К. A. Apartsin4А. V. Gorokhova5S. А. Papeshina6К. Yu. Nikolaev7К. Yu. Batueva8S. V. Yankovskaya9А. V. Tronin10G. I. Lifshits11Institute of Chemical Biology and Fundamental Medicine of SD RASResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesIrkutskaya Oblast Clinical Hospital of the “Sign of Honour” Award; Irkutsk Scientific Center of SD RASIrkutskaya Oblast Clinical Hospital of the “Sign of Honour” AwardIrkutskaya Oblast Clinical Hospital of the “Sign of Honour” AwardSRI of Therapy and Prevention Medicine — branch of SD RAS; Novosibirsk National Research State UniversitySurgut State UniversityNovosibirsk National Research State UniversityInstitute of Chemical Biology and Fundamental Medicine of SD RASInstitute of Chemical Biology and Fundamental Medicine of SD RAS; Irkutsk Scientific Center of SD RAS; Novosibirsk National Research State UniversityAim. To assess the association of efficacy and safety endpoints with simultaneous carriage of polymorphic variants of the gene CYP2C19: rs4244285 (*2), and rs12248560 (*17) in treatment with clopidogrel.Material and methods. In the study, 289 patients included, from large cities of Siberia, underwent coronary stenting for acute coronary syndrome. All participants were assessed for alleles CYP2C19*2, *3, *17, and clinical outcomes were followed for 30 days (thrombotic complications, bleedings).Results. It was found that simultaneous carriage of CYP2C19*2 and CYP2C19*17 alleles is associated with the risk of serious adverse events development of thrombotic origin comparing to the absence of such polymorphism carriage (p=0,016), and with general adverse events risk related to insufficiency of clopidogrel action (р=0,046).Conclusion. According to the study results, subjects with the *2/*17 carriage should be classified to a delayed clopidogrel metabolism group, as in the group definite and probable stent thrombosis were found significantly more prevalent.https://russjcardiol.elpub.ru/jour/article/view/2522cyp2с19clopidogrelstent thrombosis |
| spellingShingle | Е. М. Zelenskaya О. L. Barbarash V. I. Ganyukov N. A. Kochergin К. A. Apartsin А. V. Gorokhova S. А. Papeshina К. Yu. Nikolaev К. Yu. Batueva S. V. Yankovskaya А. V. Tronin G. I. Lifshits THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL Российский кардиологический журнал cyp2с19 clopidogrel stent thrombosis |
| title | THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL |
| title_full | THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL |
| title_fullStr | THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL |
| title_full_unstemmed | THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL |
| title_short | THE PROTOCOL: INFLUENCE OF THE COMBINATION CARRIAGE СУР2С19*2 AND *17 ON EFFICACY OF CLOPIDOGREL |
| title_sort | protocol influence of the combination carriage сур2с19 2 and 17 on efficacy of clopidogrel |
| topic | cyp2с19 clopidogrel stent thrombosis |
| url | https://russjcardiol.elpub.ru/jour/article/view/2522 |
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