The effectiveness of dexamethasone as a combination therapy for COVID-19
Coronavirus disease 2019 (COVID-19) was reported as a global pandemic in March 2020 after invading many countries and leaving behind tens of thousands of infected patients in a brief time span. Approval of a few vaccines has been obtained and their efficacy of varying degrees established. Still, the...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0030 |
| _version_ | 1818209441725546496 |
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| author | Namazi Nader |
| author_facet | Namazi Nader |
| author_sort | Namazi Nader |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) was reported as a global pandemic in March 2020 after invading many countries and leaving behind tens of thousands of infected patients in a brief time span. Approval of a few vaccines has been obtained and their efficacy of varying degrees established. Still, there is no effective pharmaceutical agent for the treatment of COVID-19 though several drugs are undergoing clinical trials. Recent studies have shown that dexamethasone, a corticosteroid, can reduce the rate of COVID-19-related mortality in the intensive care unit by 35 % for patients who are on mechanical ventilation. Although variable efficacy of other combination therapies has been reported for treating COVID-19 associated with acute respiratory distress syndrome (ARDS), dexamethasone is an extensively used drug in many treatment regimens against COVID-19. The current review aims to explore the role of dexamethasone as an efficient combination treatment for COVID-19. |
| first_indexed | 2024-12-12T05:00:46Z |
| format | Article |
| id | doaj.art-6c968d8be64544ab85efb622c1774666 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-12T05:00:46Z |
| publishDate | 2022-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-6c968d8be64544ab85efb622c17746662022-12-22T00:37:14ZengSciendoActa Pharmaceutica1846-95582022-09-0172334535810.2478/acph-2022-0030The effectiveness of dexamethasone as a combination therapy for COVID-19Namazi Nader0Pharmaceutics and Pharmaceutical Technology Department College of Pharmacy, Taibah University Al MadinahAl Munawarah30001Saudi ArabiaCoronavirus disease 2019 (COVID-19) was reported as a global pandemic in March 2020 after invading many countries and leaving behind tens of thousands of infected patients in a brief time span. Approval of a few vaccines has been obtained and their efficacy of varying degrees established. Still, there is no effective pharmaceutical agent for the treatment of COVID-19 though several drugs are undergoing clinical trials. Recent studies have shown that dexamethasone, a corticosteroid, can reduce the rate of COVID-19-related mortality in the intensive care unit by 35 % for patients who are on mechanical ventilation. Although variable efficacy of other combination therapies has been reported for treating COVID-19 associated with acute respiratory distress syndrome (ARDS), dexamethasone is an extensively used drug in many treatment regimens against COVID-19. The current review aims to explore the role of dexamethasone as an efficient combination treatment for COVID-19.https://doi.org/10.2478/acph-2022-0030dexamethasoneglucocorticosteroidsacute respiratory distress syndromecoronavirus disease 2019combination therapysars-cov-2immunosuppressive |
| spellingShingle | Namazi Nader The effectiveness of dexamethasone as a combination therapy for COVID-19 Acta Pharmaceutica dexamethasone glucocorticosteroids acute respiratory distress syndrome coronavirus disease 2019 combination therapy sars-cov-2 immunosuppressive |
| title | The effectiveness of dexamethasone as a combination therapy for COVID-19 |
| title_full | The effectiveness of dexamethasone as a combination therapy for COVID-19 |
| title_fullStr | The effectiveness of dexamethasone as a combination therapy for COVID-19 |
| title_full_unstemmed | The effectiveness of dexamethasone as a combination therapy for COVID-19 |
| title_short | The effectiveness of dexamethasone as a combination therapy for COVID-19 |
| title_sort | effectiveness of dexamethasone as a combination therapy for covid 19 |
| topic | dexamethasone glucocorticosteroids acute respiratory distress syndrome coronavirus disease 2019 combination therapy sars-cov-2 immunosuppressive |
| url | https://doi.org/10.2478/acph-2022-0030 |
| work_keys_str_mv | AT namazinader theeffectivenessofdexamethasoneasacombinationtherapyforcovid19 AT namazinader effectivenessofdexamethasoneasacombinationtherapyforcovid19 |