The importance of cytokines for the atopic dermatitis pathogenesis
The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genet...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2018-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/615 |
| _version_ | 1797875241373925376 |
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| author | E. E. Varlamov A. N. Pampura V. S. Sukhorukov |
| author_facet | E. E. Varlamov A. N. Pampura V. S. Sukhorukov |
| author_sort | E. E. Varlamov |
| collection | DOAJ |
| description | The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. |
| first_indexed | 2024-04-10T01:44:31Z |
| format | Article |
| id | doaj.art-6c96d094c5964891b8ea8522f8fd240b |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:44:31Z |
| publishDate | 2018-03-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-6c96d094c5964891b8ea8522f8fd240b2023-03-13T09:12:44ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282018-03-01631283310.21508/1027-4065-2018-63-1-28-33544The importance of cytokines for the atopic dermatitis pathogenesisE. E. Varlamov0A. N. Pampura1V. S. Sukhorukov2ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова, МоскваОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова, МоскваОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова, МоскваThe atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well.https://www.ped-perinatology.ru/jour/article/view/615детиатопический дерматитпатогенезцитокины |
| spellingShingle | E. E. Varlamov A. N. Pampura V. S. Sukhorukov The importance of cytokines for the atopic dermatitis pathogenesis Rossijskij Vestnik Perinatologii i Pediatrii дети атопический дерматит патогенез цитокины |
| title | The importance of cytokines for the atopic dermatitis pathogenesis |
| title_full | The importance of cytokines for the atopic dermatitis pathogenesis |
| title_fullStr | The importance of cytokines for the atopic dermatitis pathogenesis |
| title_full_unstemmed | The importance of cytokines for the atopic dermatitis pathogenesis |
| title_short | The importance of cytokines for the atopic dermatitis pathogenesis |
| title_sort | importance of cytokines for the atopic dermatitis pathogenesis |
| topic | дети атопический дерматит патогенез цитокины |
| url | https://www.ped-perinatology.ru/jour/article/view/615 |
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