Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia
Preeclampsia is a common obstetric complication associated with pregnancy and it endangers lives of the mother and the infant. The histopathological changes associated with preeclampsia include systemic endothelial dysfunction, persistent inflammatory state, and coagulation and fibrinolysis dysregul...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.01236/full |
| _version_ | 1818988074233757696 |
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| author | Cha Han Lulu Han Pengzhu Huang Yuanyuan Chen Yingmei Wang Fengxia Xue |
| author_facet | Cha Han Lulu Han Pengzhu Huang Yuanyuan Chen Yingmei Wang Fengxia Xue |
| author_sort | Cha Han |
| collection | DOAJ |
| description | Preeclampsia is a common obstetric complication associated with pregnancy and it endangers lives of the mother and the infant. The histopathological changes associated with preeclampsia include systemic endothelial dysfunction, persistent inflammatory state, and coagulation and fibrinolysis dysregulations. Preeclampsia is considered to be caused by the systemic vasoconstriction of small arteries and disruption of the endothelial integrity, resulting in hypertension, proteinuria, and multiple organ dysfunction. However, mediators that trigger or propagate the pathology of preeclampsia remain poorly defined. Syncytiotrophoblast-derived extracellular vesicles (SDEVs) are increasingly recognized as a key mediator for the development of preeclampsia, but the underlying mechanisms through which these SDEVs are released and induce systemic responses are not fully understood. This review focuses on multiple roles of SDEVs in the pathogenesis of preeclampsia. |
| first_indexed | 2024-12-20T19:16:48Z |
| format | Article |
| id | doaj.art-6c987c6913ab46579e08ba466e5b9ed5 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T19:16:48Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-6c987c6913ab46579e08ba466e5b9ed52022-12-21T19:29:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-10-011010.3389/fphys.2019.01236473232Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of PreeclampsiaCha HanLulu HanPengzhu HuangYuanyuan ChenYingmei WangFengxia XuePreeclampsia is a common obstetric complication associated with pregnancy and it endangers lives of the mother and the infant. The histopathological changes associated with preeclampsia include systemic endothelial dysfunction, persistent inflammatory state, and coagulation and fibrinolysis dysregulations. Preeclampsia is considered to be caused by the systemic vasoconstriction of small arteries and disruption of the endothelial integrity, resulting in hypertension, proteinuria, and multiple organ dysfunction. However, mediators that trigger or propagate the pathology of preeclampsia remain poorly defined. Syncytiotrophoblast-derived extracellular vesicles (SDEVs) are increasingly recognized as a key mediator for the development of preeclampsia, but the underlying mechanisms through which these SDEVs are released and induce systemic responses are not fully understood. This review focuses on multiple roles of SDEVs in the pathogenesis of preeclampsia.https://www.frontiersin.org/article/10.3389/fphys.2019.01236/fullpreeclampsiaextracellular vesiclesinflammationendothelial dysfunctioncoagulation dysregulation |
| spellingShingle | Cha Han Lulu Han Pengzhu Huang Yuanyuan Chen Yingmei Wang Fengxia Xue Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia Frontiers in Physiology preeclampsia extracellular vesicles inflammation endothelial dysfunction coagulation dysregulation |
| title | Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia |
| title_full | Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia |
| title_fullStr | Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia |
| title_full_unstemmed | Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia |
| title_short | Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia |
| title_sort | syncytiotrophoblast derived extracellular vesicles in pathophysiology of preeclampsia |
| topic | preeclampsia extracellular vesicles inflammation endothelial dysfunction coagulation dysregulation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.01236/full |
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