Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations
Abstract Background Coordination compounds, in particular cobalt(II) mixed ligand complexes containing 1,10-phenantroline, have drawn the attention of many investigators as some of them are showing antimicrobial activities. Result Herein, we report three novel mixed ligand complexes of cobalt(II) ha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-05-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | http://link.springer.com/article/10.1186/s43094-020-00030-4 |
| _version_ | 1811331708000141312 |
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| author | Atakilt Abebe Yosef Bayeh Minale Belay Tesfay Gebretsadik Madhu Thomas Wolfgang Linert |
| author_facet | Atakilt Abebe Yosef Bayeh Minale Belay Tesfay Gebretsadik Madhu Thomas Wolfgang Linert |
| author_sort | Atakilt Abebe |
| collection | DOAJ |
| description | Abstract Background Coordination compounds, in particular cobalt(II) mixed ligand complexes containing 1,10-phenantroline, have drawn the attention of many investigators as some of them are showing antimicrobial activities. Result Herein, we report three novel mixed ligand complexes of cobalt(II) having the formulae [Co(L 1)2(H2O)2]Cl2, [Co(L 1)2(L 2)(H2O)]Cl2 and [Co2(L 1)4(L 2)2(L 3)]Cl4 (L 1 = 1,10-phenanthroline, L 2 = adenine, L 3 = 1,3-diaminepropane) were synthesized and characterized by elemental analysis, conductivity measurement, infrared, and UV-Vis spectroscopic techniques. Octahedral geometries are proposed to all the complexes. In vitro antibacterial activities of the ligands, salt, and metal complexes were tested on four pathogenic bacteria (Staphylococcus aureus, Salmonella typhus, Escherichia coli, and Staphylococcus epidermis) using disc diffusion method. Conclusions It is interesting to note that the newly synthesized cobalt(II) complexes are active against gram negative bacteria (Escherichia coli and Klebsiella pneumoniae) even though cobalt(II) complexes are well known for their activity against gram positive bacteria. |
| first_indexed | 2024-04-13T16:24:48Z |
| format | Article |
| id | doaj.art-6c994919105449e0bf5fc7fe77bdbd28 |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-04-13T16:24:48Z |
| publishDate | 2020-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-6c994919105449e0bf5fc7fe77bdbd282022-12-22T02:39:46ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532020-05-01611910.1186/s43094-020-00030-4Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigationsAtakilt Abebe0Yosef Bayeh1Minale Belay2Tesfay Gebretsadik3Madhu Thomas4Wolfgang Linert5Department of Chemistry, College of Sciences, Bahir Dar UniversityDepartment of Industrial Chemistry, College of Applied Sciences, Addis Ababa Science and Technology UniversityDepartment of Chemistry, College of Sciences, Bahir Dar UniversityDepartment of Industrial Chemistry, College of Applied Sciences, Addis Ababa Science and Technology UniversityDepartment of Industrial Chemistry, College of Applied Sciences, Addis Ababa Science and Technology UniversityInstitute of Applied Synthetic Chemistry, Vienna University of TechnologyAbstract Background Coordination compounds, in particular cobalt(II) mixed ligand complexes containing 1,10-phenantroline, have drawn the attention of many investigators as some of them are showing antimicrobial activities. Result Herein, we report three novel mixed ligand complexes of cobalt(II) having the formulae [Co(L 1)2(H2O)2]Cl2, [Co(L 1)2(L 2)(H2O)]Cl2 and [Co2(L 1)4(L 2)2(L 3)]Cl4 (L 1 = 1,10-phenanthroline, L 2 = adenine, L 3 = 1,3-diaminepropane) were synthesized and characterized by elemental analysis, conductivity measurement, infrared, and UV-Vis spectroscopic techniques. Octahedral geometries are proposed to all the complexes. In vitro antibacterial activities of the ligands, salt, and metal complexes were tested on four pathogenic bacteria (Staphylococcus aureus, Salmonella typhus, Escherichia coli, and Staphylococcus epidermis) using disc diffusion method. Conclusions It is interesting to note that the newly synthesized cobalt(II) complexes are active against gram negative bacteria (Escherichia coli and Klebsiella pneumoniae) even though cobalt(II) complexes are well known for their activity against gram positive bacteria.http://link.springer.com/article/10.1186/s43094-020-00030-4BinuclearCobalt(II) complex1,10-PhenanthrolineAdenine1,3-DiaminopropaneAntibacterial activity |
| spellingShingle | Atakilt Abebe Yosef Bayeh Minale Belay Tesfay Gebretsadik Madhu Thomas Wolfgang Linert Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations Future Journal of Pharmaceutical Sciences Binuclear Cobalt(II) complex 1,10-Phenanthroline Adenine 1,3-Diaminopropane Antibacterial activity |
| title | Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations |
| title_full | Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations |
| title_fullStr | Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations |
| title_full_unstemmed | Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations |
| title_short | Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations |
| title_sort | mono and binuclear cobalt ii mixed ligand complexes containing 1 10 phenanthroline and adenine using 1 3 diaminopropane as a spacer synthesis characterization and antibacterial activity investigations |
| topic | Binuclear Cobalt(II) complex 1,10-Phenanthroline Adenine 1,3-Diaminopropane Antibacterial activity |
| url | http://link.springer.com/article/10.1186/s43094-020-00030-4 |
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