Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis
Abstract Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis after induction therapy is unknown....
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-56543-y |
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| author | Fumie Shimada Yusuke Yoshimatsu Tomohisa Sujino Tomohiro Fukuda Yasuhiro Aoki Yukie Hayashi Anna Tojo Takaaki Kawaguchi Hiroki Kiyohara Shinya Sugimoto Kosaku Nanki Yohei Mikami Kentaro Miyamoto Kaoru Takabayashi Naoki Hosoe Motohiko Kato Haruhiko Ogata Makoto Naganuma Takanori Kanai |
| author_facet | Fumie Shimada Yusuke Yoshimatsu Tomohisa Sujino Tomohiro Fukuda Yasuhiro Aoki Yukie Hayashi Anna Tojo Takaaki Kawaguchi Hiroki Kiyohara Shinya Sugimoto Kosaku Nanki Yohei Mikami Kentaro Miyamoto Kaoru Takabayashi Naoki Hosoe Motohiko Kato Haruhiko Ogata Makoto Naganuma Takanori Kanai |
| author_sort | Fumie Shimada |
| collection | DOAJ |
| description | Abstract Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis after induction therapy is unknown. Moreover, the clinical features of patients who relapsed within 52 weeks after the discontinuation of indigo naturalis are unclear. This study aimed to assess the clinical outcomes of patients with ulcerative colitis after discontinuation of indigo naturalis and to identify potential markers responsible for relapse. This single-center retrospective study investigated the follow-up of 72 patients who achieved a clinical response 8 weeks after indigo naturalis treatment. We observed relapse in patients with ulcerative colitis after the discontinuation of indigo naturalis. We analyzed the factors predicting long-term outcomes after discontinuation of indigo naturalis. Relapse was observed in 24%, 57%, and 71% of patients at 8, 26, and 52 weeks, respectively. There were no predictive markers in patients who relapsed within 52 weeks after the discontinuation of indigo naturalis. The ulcerative colitis relapse rate after indigo naturalis discontinuation was high. Follow-up treatment is required after the discontinuation of indigo naturalis in patients with ulcerative colitis. |
| first_indexed | 2024-04-25T01:05:59Z |
| format | Article |
| id | doaj.art-6c997f5690914229aa3941149ed3c29a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-25T01:05:59Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6c997f5690914229aa3941149ed3c29a2024-03-10T12:12:37ZengNature PortfolioScientific Reports2045-23222024-03-011411810.1038/s41598-024-56543-yClinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalisFumie Shimada0Yusuke Yoshimatsu1Tomohisa Sujino2Tomohiro Fukuda3Yasuhiro Aoki4Yukie Hayashi5Anna Tojo6Takaaki Kawaguchi7Hiroki Kiyohara8Shinya Sugimoto9Kosaku Nanki10Yohei Mikami11Kentaro Miyamoto12Kaoru Takabayashi13Naoki Hosoe14Motohiko Kato15Haruhiko Ogata16Makoto Naganuma17Takanori Kanai18Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of MedicineCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of MedicineCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of MedicineCenter for Diagnostic and Therapeutic Endoscopy, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of MedicineAbstract Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis after induction therapy is unknown. Moreover, the clinical features of patients who relapsed within 52 weeks after the discontinuation of indigo naturalis are unclear. This study aimed to assess the clinical outcomes of patients with ulcerative colitis after discontinuation of indigo naturalis and to identify potential markers responsible for relapse. This single-center retrospective study investigated the follow-up of 72 patients who achieved a clinical response 8 weeks after indigo naturalis treatment. We observed relapse in patients with ulcerative colitis after the discontinuation of indigo naturalis. We analyzed the factors predicting long-term outcomes after discontinuation of indigo naturalis. Relapse was observed in 24%, 57%, and 71% of patients at 8, 26, and 52 weeks, respectively. There were no predictive markers in patients who relapsed within 52 weeks after the discontinuation of indigo naturalis. The ulcerative colitis relapse rate after indigo naturalis discontinuation was high. Follow-up treatment is required after the discontinuation of indigo naturalis in patients with ulcerative colitis.https://doi.org/10.1038/s41598-024-56543-yIndigo naturalisUlcerative colitisRelapseDiscontinuation |
| spellingShingle | Fumie Shimada Yusuke Yoshimatsu Tomohisa Sujino Tomohiro Fukuda Yasuhiro Aoki Yukie Hayashi Anna Tojo Takaaki Kawaguchi Hiroki Kiyohara Shinya Sugimoto Kosaku Nanki Yohei Mikami Kentaro Miyamoto Kaoru Takabayashi Naoki Hosoe Motohiko Kato Haruhiko Ogata Makoto Naganuma Takanori Kanai Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis Scientific Reports Indigo naturalis Ulcerative colitis Relapse Discontinuation |
| title | Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis |
| title_full | Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis |
| title_fullStr | Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis |
| title_full_unstemmed | Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis |
| title_short | Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis |
| title_sort | clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis |
| topic | Indigo naturalis Ulcerative colitis Relapse Discontinuation |
| url | https://doi.org/10.1038/s41598-024-56543-y |
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