Right dorsal colitis in horses: A multicenter retrospective study of 35 cases
Abstract Background Right dorsal colitis (RDC) is a nonsteroidal anti‐inflammatory drug (NSAID) induced, protein losing enteropathy in horses associated with a high case fatality rate. Objectives To describe signalment, NSAID usage, clinical presentations, clinical pathology, ultrasonographic findin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16884 |
| _version_ | 1797248076599001088 |
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| author | Jordan Flood David Byrne Jennifer Bauquier Gustavo Ferlini Agne Jessica C. Wise Carlos E. Medina‐Torres Kelly Wood Olivia Sullivan Allison J. Stewart |
| author_facet | Jordan Flood David Byrne Jennifer Bauquier Gustavo Ferlini Agne Jessica C. Wise Carlos E. Medina‐Torres Kelly Wood Olivia Sullivan Allison J. Stewart |
| author_sort | Jordan Flood |
| collection | DOAJ |
| description | Abstract Background Right dorsal colitis (RDC) is a nonsteroidal anti‐inflammatory drug (NSAID) induced, protein losing enteropathy in horses associated with a high case fatality rate. Objectives To describe signalment, NSAID usage, clinical presentations, clinical pathology, ultrasonographic findings, treatments, outcomes, and factors associated with survival in horses diagnosed with RDC. Animals Thirty‐five horses from 7 Australian equine hospitals diagnosed with RDC. Methods Retrospective case series. Clinical records of cases were accepted if definitively or presumptively diagnosed by an internist with RDC and had ≥3 of: hypoproteinemia or hypoalbuminemia; diarrhea with negative test results for infectious diseases; colic for which other diseases were excluded or right dorsal colon thickening on ultrasound. Descriptive data analysis was performed for categorical and continuous variables. Univariate binominal logistic regressions were used to assess factors associated with survival. Results An overdose of NSAIDs occurred in 84% (21/25) cases where dose was known. Common clinical presentations included diarrhea (69%; 22/32), colic (61%; 20/33), and tachycardia (53%, 17/32). Common clinicopathological findings included hypoalbuminemia (83%; 26/31), hypocalcaemia (79%, 23/29), and hyperlactatemia (77%, 14/18). The right dorsal colon wall appeared subjectively thickened in 77% (24/31) cases using ultrasonography. Case fatality rate was 43% (15/35). Odds of survival significantly decreased with increasing heart rate (odds 0.84, 95% CI = 0.71‐0.92, P = .01), packed cell volume (odds 0.91, 95% CI 0.82‐0.98, P = .05) and abnormal appearance of mucous membranes (odds 0.05, 95% CI 0.005‐0.28, P = .001) on hospital presentation. Conclusions and Clinical Importance An overdose of NSAIDs is common in horses diagnosed with RDC. Serum albumin concentrations should be monitored in horses receiving a prolonged course of NSAIDs. Overall prognosis for RDC remains fair. |
| first_indexed | 2024-03-09T00:20:24Z |
| format | Article |
| id | doaj.art-6c99fcfc1f844aa9846fa8519b1e5833 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-24T20:08:50Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-6c99fcfc1f844aa9846fa8519b1e58332024-03-23T17:56:17ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-11-013762535254310.1111/jvim.16884Right dorsal colitis in horses: A multicenter retrospective study of 35 casesJordan Flood0David Byrne1Jennifer Bauquier2Gustavo Ferlini Agne3Jessica C. Wise4Carlos E. Medina‐Torres5Kelly Wood6Olivia Sullivan7Allison J. Stewart8School of Veterinary Science University of Queensland Gatton Queensland AustraliaSchool of Veterinary Medicine Murdoch University Perth Western Australia AustraliaMelbourne Veterinary School University of Melbourne Melbourne Victoria AustraliaSchool of Animal and Veterinary Sciences University of Adelaide Adelaide South Australia AustraliaSchool of Animal and Veterinary Sciences Charles Sturt University Wagga Wagga New South Wales AustraliaSchool of Veterinary Science University of Queensland Gatton Queensland AustraliaSchool of Veterinary Science University of Queensland Gatton Queensland AustraliaMelbourne Veterinary School University of Melbourne Melbourne Victoria AustraliaSchool of Veterinary Science University of Queensland Gatton Queensland AustraliaAbstract Background Right dorsal colitis (RDC) is a nonsteroidal anti‐inflammatory drug (NSAID) induced, protein losing enteropathy in horses associated with a high case fatality rate. Objectives To describe signalment, NSAID usage, clinical presentations, clinical pathology, ultrasonographic findings, treatments, outcomes, and factors associated with survival in horses diagnosed with RDC. Animals Thirty‐five horses from 7 Australian equine hospitals diagnosed with RDC. Methods Retrospective case series. Clinical records of cases were accepted if definitively or presumptively diagnosed by an internist with RDC and had ≥3 of: hypoproteinemia or hypoalbuminemia; diarrhea with negative test results for infectious diseases; colic for which other diseases were excluded or right dorsal colon thickening on ultrasound. Descriptive data analysis was performed for categorical and continuous variables. Univariate binominal logistic regressions were used to assess factors associated with survival. Results An overdose of NSAIDs occurred in 84% (21/25) cases where dose was known. Common clinical presentations included diarrhea (69%; 22/32), colic (61%; 20/33), and tachycardia (53%, 17/32). Common clinicopathological findings included hypoalbuminemia (83%; 26/31), hypocalcaemia (79%, 23/29), and hyperlactatemia (77%, 14/18). The right dorsal colon wall appeared subjectively thickened in 77% (24/31) cases using ultrasonography. Case fatality rate was 43% (15/35). Odds of survival significantly decreased with increasing heart rate (odds 0.84, 95% CI = 0.71‐0.92, P = .01), packed cell volume (odds 0.91, 95% CI 0.82‐0.98, P = .05) and abnormal appearance of mucous membranes (odds 0.05, 95% CI 0.005‐0.28, P = .001) on hospital presentation. Conclusions and Clinical Importance An overdose of NSAIDs is common in horses diagnosed with RDC. Serum albumin concentrations should be monitored in horses receiving a prolonged course of NSAIDs. Overall prognosis for RDC remains fair.https://doi.org/10.1111/jvim.16884colicdiarrheanonsteroidal anti‐inflammatory drugsphenylbutazone |
| spellingShingle | Jordan Flood David Byrne Jennifer Bauquier Gustavo Ferlini Agne Jessica C. Wise Carlos E. Medina‐Torres Kelly Wood Olivia Sullivan Allison J. Stewart Right dorsal colitis in horses: A multicenter retrospective study of 35 cases Journal of Veterinary Internal Medicine colic diarrhea nonsteroidal anti‐inflammatory drugs phenylbutazone |
| title | Right dorsal colitis in horses: A multicenter retrospective study of 35 cases |
| title_full | Right dorsal colitis in horses: A multicenter retrospective study of 35 cases |
| title_fullStr | Right dorsal colitis in horses: A multicenter retrospective study of 35 cases |
| title_full_unstemmed | Right dorsal colitis in horses: A multicenter retrospective study of 35 cases |
| title_short | Right dorsal colitis in horses: A multicenter retrospective study of 35 cases |
| title_sort | right dorsal colitis in horses a multicenter retrospective study of 35 cases |
| topic | colic diarrhea nonsteroidal anti‐inflammatory drugs phenylbutazone |
| url | https://doi.org/10.1111/jvim.16884 |
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