BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression
Cancer: a drug combination for combating melanoma Drugs that target proteins involved in issuing stop and start commands to cancer-related genes help to sensitize melanoma cells to a widely used anti-cancer therapy, leading to tumor shrinkage in mice. Furong Zeng from Central South University in Cha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-00936-y |
| _version_ | 1797865474782920704 |
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| author | Furong Zeng Yayun Li Yu Meng Huiyan Sun Yi He Mingzhu Yin Xiang Chen Guangtong Deng |
| author_facet | Furong Zeng Yayun Li Yu Meng Huiyan Sun Yi He Mingzhu Yin Xiang Chen Guangtong Deng |
| author_sort | Furong Zeng |
| collection | DOAJ |
| description | Cancer: a drug combination for combating melanoma Drugs that target proteins involved in issuing stop and start commands to cancer-related genes help to sensitize melanoma cells to a widely used anti-cancer therapy, leading to tumor shrinkage in mice. Furong Zeng from Central South University in Changsha, China, and colleagues screened 240 approved anti-cancer agents in search of molecules that work synergistically with a BET inhibitor, an inhibitor of these proteins, to induce the death of melanoma cells. They found that a protein targeted by BET inhibitors (JQ1 and NHWD-870) regulates a growth factor protein, whose altered expression then helps to sensitize melanoma cells to sunitinib. Sunitinib is approved to treat several types of cancer and works by targeting many different kinds of kinase enzymes. The combination of BET inhibitors and sunitinib showed synergistic antitumor effects in a mouse model of melanoma. |
| first_indexed | 2024-04-09T23:09:02Z |
| format | Article |
| id | doaj.art-6c9ad365f0be4d5da61823da135edeae |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-04-09T23:09:02Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-6c9ad365f0be4d5da61823da135edeae2023-03-22T10:31:30ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-02-0155236437610.1038/s12276-023-00936-yBET inhibitors synergize with sunitinib in melanoma through GDF15 suppressionFurong Zeng0Yayun Li1Yu Meng2Huiyan Sun3Yi He4Mingzhu Yin5Xiang Chen6Guangtong Deng7Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South UniversityCancer: a drug combination for combating melanoma Drugs that target proteins involved in issuing stop and start commands to cancer-related genes help to sensitize melanoma cells to a widely used anti-cancer therapy, leading to tumor shrinkage in mice. Furong Zeng from Central South University in Changsha, China, and colleagues screened 240 approved anti-cancer agents in search of molecules that work synergistically with a BET inhibitor, an inhibitor of these proteins, to induce the death of melanoma cells. They found that a protein targeted by BET inhibitors (JQ1 and NHWD-870) regulates a growth factor protein, whose altered expression then helps to sensitize melanoma cells to sunitinib. Sunitinib is approved to treat several types of cancer and works by targeting many different kinds of kinase enzymes. The combination of BET inhibitors and sunitinib showed synergistic antitumor effects in a mouse model of melanoma.https://doi.org/10.1038/s12276-023-00936-y |
| spellingShingle | Furong Zeng Yayun Li Yu Meng Huiyan Sun Yi He Mingzhu Yin Xiang Chen Guangtong Deng BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression Experimental and Molecular Medicine |
| title | BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression |
| title_full | BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression |
| title_fullStr | BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression |
| title_full_unstemmed | BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression |
| title_short | BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression |
| title_sort | bet inhibitors synergize with sunitinib in melanoma through gdf15 suppression |
| url | https://doi.org/10.1038/s12276-023-00936-y |
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