On the quantitative importance of omega-oxidation of fatty acids.
The relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consiste...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1978-07-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520412908 |
| _version_ | 1819290975974981632 |
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| author | I Björkhem |
| author_facet | I Björkhem |
| author_sort | I Björkhem |
| collection | DOAJ |
| description | The relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consistent with the possibility that at least a small fraction of the fatty acids may be subject to primary omega-oxidation prior to beta-oxidation in the ketotic state. The maximal figure for this pathway was calculated to be of the magnitude 5–10%. The metabolic consequences of a pathway involving primary omega-oxidation of fatty acids are discussed. |
| first_indexed | 2024-12-24T03:31:17Z |
| format | Article |
| id | doaj.art-6c9cf838962f4c24ac79c08d18007556 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-24T03:31:17Z |
| publishDate | 1978-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-6c9cf838962f4c24ac79c08d180075562022-12-21T17:17:11ZengElsevierJournal of Lipid Research0022-22751978-07-01195585590On the quantitative importance of omega-oxidation of fatty acids.I BjörkhemThe relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consistent with the possibility that at least a small fraction of the fatty acids may be subject to primary omega-oxidation prior to beta-oxidation in the ketotic state. The maximal figure for this pathway was calculated to be of the magnitude 5–10%. The metabolic consequences of a pathway involving primary omega-oxidation of fatty acids are discussed.http://www.sciencedirect.com/science/article/pii/S0022227520412908 |
| spellingShingle | I Björkhem On the quantitative importance of omega-oxidation of fatty acids. Journal of Lipid Research |
| title | On the quantitative importance of omega-oxidation of fatty acids. |
| title_full | On the quantitative importance of omega-oxidation of fatty acids. |
| title_fullStr | On the quantitative importance of omega-oxidation of fatty acids. |
| title_full_unstemmed | On the quantitative importance of omega-oxidation of fatty acids. |
| title_short | On the quantitative importance of omega-oxidation of fatty acids. |
| title_sort | on the quantitative importance of omega oxidation of fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520412908 |
| work_keys_str_mv | AT ibjorkhem onthequantitativeimportanceofomegaoxidationoffattyacids |