Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP). β-secretase inhibitors reduce Aβ levels, but mechanism-b...

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Bibliographic Details
Main Authors: Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
Alzheimer disease
APP
BACE
molecular dynamics
subcellular compartmentalization
membrane trafficking
secretase
amyloid
Neuregulin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716300754

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