Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations
BackgroundExposure to air pollution may be a risk factor for obstructive sleep apnea (OSA) because air pollution may alter body water distribution and aggravate OSA manifestations.ObjectivesThis study aimed to investigate the mediating effects of air pollution on the exacerbation of OSA severity thr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1175203/full |
| _version_ | 1797803796469907456 |
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| author | Cheng-Yu Tsai Cheng-Yu Tsai Huei-Tyng Huang Ming Liu Wun-Hao Cheng Wun-Hao Cheng Wen-Hua Hsu Yi-Chun Kuan Yi-Chun Kuan Yi-Chun Kuan Yi-Chun Kuan Arnab Majumdar Kang-Yun Lee Po-Hao Feng Chien-Hua Tseng Kuan-Yuan Chen Jiunn-Horng Kang Jiunn-Horng Kang Hsin-Chien Lee Cheng-Jung Wu Wen-Te Liu Wen-Te Liu Wen-Te Liu Wen-Te Liu |
| author_facet | Cheng-Yu Tsai Cheng-Yu Tsai Huei-Tyng Huang Ming Liu Wun-Hao Cheng Wun-Hao Cheng Wen-Hua Hsu Yi-Chun Kuan Yi-Chun Kuan Yi-Chun Kuan Yi-Chun Kuan Arnab Majumdar Kang-Yun Lee Po-Hao Feng Chien-Hua Tseng Kuan-Yuan Chen Jiunn-Horng Kang Jiunn-Horng Kang Hsin-Chien Lee Cheng-Jung Wu Wen-Te Liu Wen-Te Liu Wen-Te Liu Wen-Te Liu |
| author_sort | Cheng-Yu Tsai |
| collection | DOAJ |
| description | BackgroundExposure to air pollution may be a risk factor for obstructive sleep apnea (OSA) because air pollution may alter body water distribution and aggravate OSA manifestations.ObjectivesThis study aimed to investigate the mediating effects of air pollution on the exacerbation of OSA severity through body water distribution.MethodsThis retrospective study analyzed body composition and polysomnographic data collected from a sleep center in Northern Taiwan. Air pollution exposure was estimated using an adjusted nearest method, registered residential addresses, and data from the databases of government air quality motioning stations. Next, regression models were employed to determine the associations between estimated air pollution exposure levels (exposure for 1, 3, 6, and 12 months), OSA manifestations (sleep-disordered breathing indices and respiratory event duration), and body fluid parameters (total body water and body water distribution). The association between air pollution and OSA risk was determined.ResultsSignificant associations between OSA manifestations and short-term (1 month) exposure to PM2.5 and PM10 were identified. Similarly, significant associations were identified among total body water and body water distribution (intracellular-to-extracellular body water distribution), short-term (1 month) exposure to PM2.5 and PM10, and medium-term (3 months) exposure to PM10. Body water distribution might be a mediator that aggravates OSA manifestations, and short-term exposure to PM2.5 and PM10 may be a risk factor for OSA.ConclusionBecause exposure to PM2.5 and PM10 may be a risk factor for OSA that exacerbates OSA manifestations and exposure to particulate pollutants may affect OSA manifestations or alter body water distribution to affect OSA manifestations, mitigating exposure to particulate pollutants may improve OSA manifestations and reduce the risk of OSA. Furthermore, this study elucidated the potential mechanisms underlying the relationship between air pollution, body fluid parameters, and OSA severity. |
| first_indexed | 2024-03-13T05:26:26Z |
| format | Article |
| id | doaj.art-6c9daf6f3f34453e921077a028abde57 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-13T05:26:26Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-6c9daf6f3f34453e921077a028abde572023-06-15T05:41:29ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-06-011110.3389/fpubh.2023.11752031175203Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestationsCheng-Yu Tsai0Cheng-Yu Tsai1Huei-Tyng Huang2Ming Liu3Wun-Hao Cheng4Wun-Hao Cheng5Wen-Hua Hsu6Yi-Chun Kuan7Yi-Chun Kuan8Yi-Chun Kuan9Yi-Chun Kuan10Arnab Majumdar11Kang-Yun Lee12Po-Hao Feng13Chien-Hua Tseng14Kuan-Yuan Chen15Jiunn-Horng Kang16Jiunn-Horng Kang17Hsin-Chien Lee18Cheng-Jung Wu19Wen-Te Liu20Wen-Te Liu21Wen-Te Liu22Wen-Te Liu23Department of Civil and Environmental Engineering, Imperial College London, London, United KingdomDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDepartment of Medical Physics and Biomedical Engineering, University College London, London, United KingdomDepartment of Biology, University of Oxford, Oxfordshire, United KingdomSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, TaiwanRespiratory Therapy, Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, TaiwanSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, TaiwanSleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan0Taipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanDepartment of Civil and Environmental Engineering, Imperial College London, London, United KingdomDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan1Research Center of Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan2Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan3Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan4Department of Otolaryngology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City, TaiwanSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, TaiwanSleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan1Research Center of Artificial Intelligence in Medicine, Taipei Medical University, Taipei, TaiwanBackgroundExposure to air pollution may be a risk factor for obstructive sleep apnea (OSA) because air pollution may alter body water distribution and aggravate OSA manifestations.ObjectivesThis study aimed to investigate the mediating effects of air pollution on the exacerbation of OSA severity through body water distribution.MethodsThis retrospective study analyzed body composition and polysomnographic data collected from a sleep center in Northern Taiwan. Air pollution exposure was estimated using an adjusted nearest method, registered residential addresses, and data from the databases of government air quality motioning stations. Next, regression models were employed to determine the associations between estimated air pollution exposure levels (exposure for 1, 3, 6, and 12 months), OSA manifestations (sleep-disordered breathing indices and respiratory event duration), and body fluid parameters (total body water and body water distribution). The association between air pollution and OSA risk was determined.ResultsSignificant associations between OSA manifestations and short-term (1 month) exposure to PM2.5 and PM10 were identified. Similarly, significant associations were identified among total body water and body water distribution (intracellular-to-extracellular body water distribution), short-term (1 month) exposure to PM2.5 and PM10, and medium-term (3 months) exposure to PM10. Body water distribution might be a mediator that aggravates OSA manifestations, and short-term exposure to PM2.5 and PM10 may be a risk factor for OSA.ConclusionBecause exposure to PM2.5 and PM10 may be a risk factor for OSA that exacerbates OSA manifestations and exposure to particulate pollutants may affect OSA manifestations or alter body water distribution to affect OSA manifestations, mitigating exposure to particulate pollutants may improve OSA manifestations and reduce the risk of OSA. Furthermore, this study elucidated the potential mechanisms underlying the relationship between air pollution, body fluid parameters, and OSA severity.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1175203/fullair pollutionobstructive sleep apneaPM2.5PM10intra-to-extracellular body water distribution |
| spellingShingle | Cheng-Yu Tsai Cheng-Yu Tsai Huei-Tyng Huang Ming Liu Wun-Hao Cheng Wun-Hao Cheng Wen-Hua Hsu Yi-Chun Kuan Yi-Chun Kuan Yi-Chun Kuan Yi-Chun Kuan Arnab Majumdar Kang-Yun Lee Po-Hao Feng Chien-Hua Tseng Kuan-Yuan Chen Jiunn-Horng Kang Jiunn-Horng Kang Hsin-Chien Lee Cheng-Jung Wu Wen-Te Liu Wen-Te Liu Wen-Te Liu Wen-Te Liu Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations Frontiers in Public Health air pollution obstructive sleep apnea PM2.5 PM10 intra-to-extracellular body water distribution |
| title | Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations |
| title_full | Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations |
| title_fullStr | Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations |
| title_full_unstemmed | Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations |
| title_short | Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations |
| title_sort | associations between air pollution intracellular to extracellular water distribution and obstructive sleep apnea manifestations |
| topic | air pollution obstructive sleep apnea PM2.5 PM10 intra-to-extracellular body water distribution |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1175203/full |
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