Alginate and alginate composites for biomedical applications
Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp. and Pseudomonas sp. Owing to alginate gel forming capability, it is widely used in food, textile and paper industries; and to a lesser extent in biomedical ap...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087620306437 |
| _version_ | 1818656276813447168 |
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| author | Raha Ahmad Raus Wan Mohd Fazli Wan Nawawi Ricca Rahman Nasaruddin |
| author_facet | Raha Ahmad Raus Wan Mohd Fazli Wan Nawawi Ricca Rahman Nasaruddin |
| author_sort | Raha Ahmad Raus |
| collection | DOAJ |
| description | Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp. and Pseudomonas sp. Owing to alginate gel forming capability, it is widely used in food, textile and paper industries; and to a lesser extent in biomedical applications as biomaterial to promote wound healing and tissue regeneration. This is evident from the rising use of alginate-based dressing for heavily exuding wound and their mass availability in the market nowadays. However, alginate also has limitation. When in contact with physiological environment, alginate could gelate into softer structure, consequently limits its potential in the soft tissue regeneration and becomes inappropriate for the usage related to load bearing body parts. To cater this problem, wide range of materials have been added to alginate structure, producing sturdy composite materials. For instance, the incorporation of adhesive peptide and natural polymer or synthetic polymer to alginate moieties creates an improved composite material, which not only possesses better mechanical properties compared to native alginate, but also grants additional healing capability and promote better tissue regeneration. In addition, drug release kinetic and cell viability can be further improved when alginate composite is used as encapsulating agent. In this review, preparation of alginate and alginate composite in various forms (fibre, bead, hydrogel, and 3D-printed matrices) used for biomedical application is described first, followed by the discussion of latest trend related to alginate composite utilization in wound dressing, drug delivery, and tissue engineering applications. |
| first_indexed | 2024-12-17T03:23:01Z |
| format | Article |
| id | doaj.art-6c9e2246d8d84c73b8c1b218267a4fc3 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-17T03:23:01Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-6c9e2246d8d84c73b8c1b218267a4fc32022-12-21T22:05:27ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762021-05-01163280306Alginate and alginate composites for biomedical applicationsRaha Ahmad Raus0Wan Mohd Fazli Wan Nawawi1Ricca Rahman Nasaruddin2Department of Biotechnology Engineering, International Islamic University Malaysia, Kuala Lumpur 50728, MalaysiaDepartment of Biotechnology Engineering, International Islamic University Malaysia, Kuala Lumpur 50728, Malaysia; Nanoscience and Nanotechnology Research Group (NanoRG), International Islamic University Malaysia, Kuala Lumpur 50728, Malaysia; Corresponding author.Department of Biotechnology Engineering, International Islamic University Malaysia, Kuala Lumpur 50728, Malaysia; Nanoscience and Nanotechnology Research Group (NanoRG), International Islamic University Malaysia, Kuala Lumpur 50728, MalaysiaAlginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp. and Pseudomonas sp. Owing to alginate gel forming capability, it is widely used in food, textile and paper industries; and to a lesser extent in biomedical applications as biomaterial to promote wound healing and tissue regeneration. This is evident from the rising use of alginate-based dressing for heavily exuding wound and their mass availability in the market nowadays. However, alginate also has limitation. When in contact with physiological environment, alginate could gelate into softer structure, consequently limits its potential in the soft tissue regeneration and becomes inappropriate for the usage related to load bearing body parts. To cater this problem, wide range of materials have been added to alginate structure, producing sturdy composite materials. For instance, the incorporation of adhesive peptide and natural polymer or synthetic polymer to alginate moieties creates an improved composite material, which not only possesses better mechanical properties compared to native alginate, but also grants additional healing capability and promote better tissue regeneration. In addition, drug release kinetic and cell viability can be further improved when alginate composite is used as encapsulating agent. In this review, preparation of alginate and alginate composite in various forms (fibre, bead, hydrogel, and 3D-printed matrices) used for biomedical application is described first, followed by the discussion of latest trend related to alginate composite utilization in wound dressing, drug delivery, and tissue engineering applications.http://www.sciencedirect.com/science/article/pii/S1818087620306437AlginateAlginate compositeTissue engineeringWound dressingDrug delivery |
| spellingShingle | Raha Ahmad Raus Wan Mohd Fazli Wan Nawawi Ricca Rahman Nasaruddin Alginate and alginate composites for biomedical applications Asian Journal of Pharmaceutical Sciences Alginate Alginate composite Tissue engineering Wound dressing Drug delivery |
| title | Alginate and alginate composites for biomedical applications |
| title_full | Alginate and alginate composites for biomedical applications |
| title_fullStr | Alginate and alginate composites for biomedical applications |
| title_full_unstemmed | Alginate and alginate composites for biomedical applications |
| title_short | Alginate and alginate composites for biomedical applications |
| title_sort | alginate and alginate composites for biomedical applications |
| topic | Alginate Alginate composite Tissue engineering Wound dressing Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S1818087620306437 |
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