The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration

The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration

Abstract CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutations within the CBP gene are known to cause Rubinstein-Taybi syndrome (RSTS), a devel...

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Bibliographic Details
Main Authors: Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Severin Filser, Finn Peters, Jana Immenschuh, Malte Hellwig, Judith Niesen, Volker Mall, Birgit Ertl-Wagner, Christian Hagel, Michael Spohn, Beat Lutz, Jan Sedlacik, Daniela Indenbirken, Daniel J. Merk, Ulrich Schüller
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Creb binding protein (CREBBP
CBP)
Rubinstein-Taybi syndrome (RSTS)
Neural precursor cell migration
Adult neurogenesis
Neural differentiation
Online Access:https://doi.org/10.1186/s40478-019-0849-5

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