Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy
Background: Software-based MRI/TRUS fusion biopsy depends on the coordination of several steps, and inter-examiner differences could influence the results. The aim of this bicentric prospective study was to compare the detection rates of MRI/TRUS fusion targeted biopsy (TG) and systematic biopsy (SB...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2020-09-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202003-0014_cancer-detection-rates-and-inter-examiner-variability-of-mri-trus-fusion-targeted-biopsy-and-systematic-transre.php |
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| author | Miroslav Zalesky Jiri Stejskal Ivo Minarik Vanda Adamcova Marek Babjuk Roman Zachoval |
| author_facet | Miroslav Zalesky Jiri Stejskal Ivo Minarik Vanda Adamcova Marek Babjuk Roman Zachoval |
| author_sort | Miroslav Zalesky |
| collection | DOAJ |
| description | Background: Software-based MRI/TRUS fusion biopsy depends on the coordination of several steps, and inter-examiner differences could influence the results. The aim of this bicentric prospective study was to compare the detection rates of MRI/TRUS fusion targeted biopsy (TG) and systematic biopsy (SB), and the detection rates of examiners with different levels of previous experience in prostate biopsy. Methods: A total of 419 patients underwent MRI based on a suspicion of prostate cancer with elevated PSA levels. MRI was positive in 395 patients (221 in the first biopsy group [FB] and 174 in the repeated biopsy group [RB]). A subsequent TG, followed by a SB, was performed on these patients by four different examiners. Results: In the detection of clinically significant prostate cancer, a significant difference was found for TG+SB against SB in the RB group (35.1% vs. 25.3%, P=0.047). In the detection of clinically insignificant prostate cancer, the SB had a significantly higher detection rate than TG in both subgroups (FB: 11.9% vs. 4.7%, P=0.008; RB: 13.8% vs. 6.9%, P=0.034). A significant difference was found between the four examiners in the FB for TG (P=0.028), SB (P=0.036), and TG+SB (P=0.017). Conclusion: MRI/TRUS TG in combination with SB had significantly higher detection rates than SB in the RB group only. Differences in detection rates between examiners were dependent on the level of previous experience with TRUS guided biopsy. |
| first_indexed | 2024-12-10T13:38:40Z |
| format | Article |
| id | doaj.art-6ca13fe98aea4346bef5f11305841d91 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-10T13:38:40Z |
| publishDate | 2020-09-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-6ca13fe98aea4346bef5f11305841d912022-12-22T01:46:45ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212020-09-01164331431910.5507/bp.2019.050bio-202003-0014Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsyMiroslav Zalesky0Jiri Stejskal1Ivo Minarik2Vanda Adamcova3Marek Babjuk4Roman Zachoval5Department of Urology, Thomayer Hospital and 3rd Faculty of Medicine, Charles University, Prague, Czech RepublicDepartment of Urology, Thomayer Hospital and 3rd Faculty of Medicine, Charles University, Prague, Czech RepublicDepartment of Urology, 2Department of Urology, Thomayer Hospital and 3rd Faculty of Medicine, Charles University, Prague, Czech RepublicDepartment of Urology, 2Department of Urology, Thomayer Hospital and 3rd Faculty of Medicine, Charles University, Prague, Czech RepublicBackground: Software-based MRI/TRUS fusion biopsy depends on the coordination of several steps, and inter-examiner differences could influence the results. The aim of this bicentric prospective study was to compare the detection rates of MRI/TRUS fusion targeted biopsy (TG) and systematic biopsy (SB), and the detection rates of examiners with different levels of previous experience in prostate biopsy. Methods: A total of 419 patients underwent MRI based on a suspicion of prostate cancer with elevated PSA levels. MRI was positive in 395 patients (221 in the first biopsy group [FB] and 174 in the repeated biopsy group [RB]). A subsequent TG, followed by a SB, was performed on these patients by four different examiners. Results: In the detection of clinically significant prostate cancer, a significant difference was found for TG+SB against SB in the RB group (35.1% vs. 25.3%, P=0.047). In the detection of clinically insignificant prostate cancer, the SB had a significantly higher detection rate than TG in both subgroups (FB: 11.9% vs. 4.7%, P=0.008; RB: 13.8% vs. 6.9%, P=0.034). A significant difference was found between the four examiners in the FB for TG (P=0.028), SB (P=0.036), and TG+SB (P=0.017). Conclusion: MRI/TRUS TG in combination with SB had significantly higher detection rates than SB in the RB group only. Differences in detection rates between examiners were dependent on the level of previous experience with TRUS guided biopsy.https://biomed.papers.upol.cz/artkey/bio-202003-0014_cancer-detection-rates-and-inter-examiner-variability-of-mri-trus-fusion-targeted-biopsy-and-systematic-transre.phpbiopsydiagnostic imagingfusionmagnetic resonanceprostate cancer |
| spellingShingle | Miroslav Zalesky Jiri Stejskal Ivo Minarik Vanda Adamcova Marek Babjuk Roman Zachoval Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy Biomedical Papers biopsy diagnostic imaging fusion magnetic resonance prostate cancer |
| title | Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy |
| title_full | Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy |
| title_fullStr | Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy |
| title_full_unstemmed | Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy |
| title_short | Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy |
| title_sort | cancer detection rates and inter examiner variability of mri trus fusion targeted biopsy and systematic transrectal biopsy |
| topic | biopsy diagnostic imaging fusion magnetic resonance prostate cancer |
| url | https://biomed.papers.upol.cz/artkey/bio-202003-0014_cancer-detection-rates-and-inter-examiner-variability-of-mri-trus-fusion-targeted-biopsy-and-systematic-transre.php |
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