Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a
Acid-sensing ion channels (ASICs) are members of the degenerin/epithelial sodium channel superfamily. They are extracellular pH sensors that are activated by protons. Among all ASICs, ASIC1a is one of the most intensively studied isoforms because of its unique ability to be permeable to Ca2+. In add...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.596304/full |
| _version_ | 1818972655158558720 |
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| author | Yayun Xu Yayun Xu Yayun Xu Feihu Chen Feihu Chen Feihu Chen |
| author_facet | Yayun Xu Yayun Xu Yayun Xu Feihu Chen Feihu Chen Feihu Chen |
| author_sort | Yayun Xu |
| collection | DOAJ |
| description | Acid-sensing ion channels (ASICs) are members of the degenerin/epithelial sodium channel superfamily. They are extracellular pH sensors that are activated by protons. Among all ASICs, ASIC1a is one of the most intensively studied isoforms because of its unique ability to be permeable to Ca2+. In addition, it is considered to contribute to various pathophysiological conditions. As a membrane proton receptor, the number of ASIC1a present on the cell surface determines its physiological and pathological functions, and this number partially depends on protein synthesis, degradation, and membrane trafficking processes. Recently, several studies have shown that various factors affect these processes. Therefore, this review elucidated the major factors and underlying molecular mechanisms affecting ASIC1a protein expression and membrane trafficking. |
| first_indexed | 2024-12-20T15:11:43Z |
| format | Article |
| id | doaj.art-6ca22665d15e4287ae3fe76666919053 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-20T15:11:43Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6ca22665d15e4287ae3fe766669190532022-12-21T19:36:18ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-10-01810.3389/fcell.2020.596304596304Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1aYayun Xu0Yayun Xu1Yayun Xu2Feihu Chen3Feihu Chen4Feihu Chen5Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaAcid-sensing ion channels (ASICs) are members of the degenerin/epithelial sodium channel superfamily. They are extracellular pH sensors that are activated by protons. Among all ASICs, ASIC1a is one of the most intensively studied isoforms because of its unique ability to be permeable to Ca2+. In addition, it is considered to contribute to various pathophysiological conditions. As a membrane proton receptor, the number of ASIC1a present on the cell surface determines its physiological and pathological functions, and this number partially depends on protein synthesis, degradation, and membrane trafficking processes. Recently, several studies have shown that various factors affect these processes. Therefore, this review elucidated the major factors and underlying molecular mechanisms affecting ASIC1a protein expression and membrane trafficking.https://www.frontiersin.org/articles/10.3389/fcell.2020.596304/fullfactorsmembrane traffickingmolecular mechanismsprotein expressionacid-sensing ion channel 1a |
| spellingShingle | Yayun Xu Yayun Xu Yayun Xu Feihu Chen Feihu Chen Feihu Chen Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a Frontiers in Cell and Developmental Biology factors membrane trafficking molecular mechanisms protein expression acid-sensing ion channel 1a |
| title | Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a |
| title_full | Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a |
| title_fullStr | Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a |
| title_full_unstemmed | Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a |
| title_short | Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a |
| title_sort | factors and molecular mechanisms influencing the protein synthesis degradation and membrane trafficking of asic1a |
| topic | factors membrane trafficking molecular mechanisms protein expression acid-sensing ion channel 1a |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.596304/full |
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