Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia
<p>Abstract</p> <p>Background</p> <p>This study assessed the gender-specific influence of the <it>cholesteryl ester transfer protein </it>(TaqIB, I405V) and <it>lipoprotein lipase </it>(S447X) polymorphisms on the response to an oral fat toleranc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-06-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/8/1/24 |
| _version_ | 1819202772374913024 |
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| author | Marvaki Christina Hatzigeorgiou Georgios Mihas Constantinos Kostakou Peggy M Kolovou Genovefa D Anagnostopoulou Katherine K Degiannis Dimitrios Mikhailidis Dimitri P Cokkinos Dennis V |
| author_facet | Marvaki Christina Hatzigeorgiou Georgios Mihas Constantinos Kostakou Peggy M Kolovou Genovefa D Anagnostopoulou Katherine K Degiannis Dimitrios Mikhailidis Dimitri P Cokkinos Dennis V |
| author_sort | Marvaki Christina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study assessed the gender-specific influence of the <it>cholesteryl ester transfer protein </it>(TaqIB, I405V) and <it>lipoprotein lipase </it>(S447X) polymorphisms on the response to an oral fat tolerance test in heterozygotes for familial hypercholesterolaemia.</p> <p>Methods</p> <p>We selected and genotyped 80 men and postmenopausal women heterozygous for familial hypercholesterolaemia (main group) as well as 11 healthy control subjects. Patients were subgrouped based on their response to oral fat tolerance test. The oral fat tolerance test was defined as pathological when postprandial triglyceride concentration was higher than the highest triglyceride concentration observed in healthy subjects (220 mg/dl) at any time (2, 4, 6 or 8 h).</p> <p>Results</p> <p>In the pathological subgroup, men had significantly higher incremental area under the curve after oral fat tolerance test than postmenopausal women. Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup.</p> <p>Conclusion</p> <p>In conclusion, it seems that gender and TaqIB polymorphism of the <it>cholesteryl ester transfer protein </it>gene were both associated with the distribution of triglyceride values after oral fat tolerance test, only in subjects with a pathological response to oral fat tolerance test. Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2. However, further investigations in larger populations are required to replicate and confirm these findings.</p> |
| first_indexed | 2024-12-23T04:09:20Z |
| format | Article |
| id | doaj.art-6ca5e1df574e4151872164de70f856a7 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-23T04:09:20Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-6ca5e1df574e4151872164de70f856a72022-12-21T18:00:33ZengBMCLipids in Health and Disease1476-511X2009-06-01812410.1186/1476-511X-8-24Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemiaMarvaki ChristinaHatzigeorgiou GeorgiosMihas ConstantinosKostakou Peggy MKolovou Genovefa DAnagnostopoulou Katherine KDegiannis DimitriosMikhailidis Dimitri PCokkinos Dennis V<p>Abstract</p> <p>Background</p> <p>This study assessed the gender-specific influence of the <it>cholesteryl ester transfer protein </it>(TaqIB, I405V) and <it>lipoprotein lipase </it>(S447X) polymorphisms on the response to an oral fat tolerance test in heterozygotes for familial hypercholesterolaemia.</p> <p>Methods</p> <p>We selected and genotyped 80 men and postmenopausal women heterozygous for familial hypercholesterolaemia (main group) as well as 11 healthy control subjects. Patients were subgrouped based on their response to oral fat tolerance test. The oral fat tolerance test was defined as pathological when postprandial triglyceride concentration was higher than the highest triglyceride concentration observed in healthy subjects (220 mg/dl) at any time (2, 4, 6 or 8 h).</p> <p>Results</p> <p>In the pathological subgroup, men had significantly higher incremental area under the curve after oral fat tolerance test than postmenopausal women. Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup.</p> <p>Conclusion</p> <p>In conclusion, it seems that gender and TaqIB polymorphism of the <it>cholesteryl ester transfer protein </it>gene were both associated with the distribution of triglyceride values after oral fat tolerance test, only in subjects with a pathological response to oral fat tolerance test. Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2. However, further investigations in larger populations are required to replicate and confirm these findings.</p>http://www.lipidworld.com/content/8/1/24 |
| spellingShingle | Marvaki Christina Hatzigeorgiou Georgios Mihas Constantinos Kostakou Peggy M Kolovou Genovefa D Anagnostopoulou Katherine K Degiannis Dimitrios Mikhailidis Dimitri P Cokkinos Dennis V Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia Lipids in Health and Disease |
| title | Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia |
| title_full | Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia |
| title_fullStr | Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia |
| title_full_unstemmed | Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia |
| title_short | Sex-associated effect of <it>CETP </it>and <it>LPL </it>polymorphisms on postprandial lipids in familial hypercholesterolaemia |
| title_sort | sex associated effect of it cetp it and it lpl it polymorphisms on postprandial lipids in familial hypercholesterolaemia |
| url | http://www.lipidworld.com/content/8/1/24 |
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