Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2

Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2

Lamellarin α 20-sulfate is a cell-impenetrable marine alkaloid that can suppress infection that is mediated by the envelope glycoprotein of human immunodeficiency virus type 1. We explored the antiviral action and mechanisms of this alkaloid against emerging enveloped RNA viruses that use endocytosi...

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Bibliographic Details
Main Authors: Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, Yoshinao Kubo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
marine alkaloid
lamellarin α 20-sulfate
emerging viruses
antiviral action
antiviral mechanism
pseudotyped lentiviral vector
Online Access:https://www.mdpi.com/1999-4915/14/4/816

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