Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection

COVID-19 infection poses an important clinical therapeutic problem, especially in patients with coexistent diseases such as type 2 diabetes. Potential pathogenetic links between COVID-19 and diabetes include inflammation, effects on glucose homeostasis, haemoglobin deoxygenation, altered immune stat...

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Main Authors: Weronika Bielka, Agnieszka Przezak, Andrzej Pawlik
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/14/7605
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author Weronika Bielka
Agnieszka Przezak
Andrzej Pawlik
author_facet Weronika Bielka
Agnieszka Przezak
Andrzej Pawlik
author_sort Weronika Bielka
collection DOAJ
description COVID-19 infection poses an important clinical therapeutic problem, especially in patients with coexistent diseases such as type 2 diabetes. Potential pathogenetic links between COVID-19 and diabetes include inflammation, effects on glucose homeostasis, haemoglobin deoxygenation, altered immune status and activation of the renin-angiotensin-aldosterone system (RAAS). Moreover, drugs often used in the clinical care of diabetes (dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, metformin and insulin) may influence the course of SARS-CoV-2 infection, so it is very important to verify their effectiveness and safety. This review summarises the new advances in diabetes therapy and COVID-19 and provides clinical recommendations that are essential for medical doctors and for patients suffering from type 2 diabetes.
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spelling doaj.art-6ca93d7f18a44927a6105df7ebfc10eb2023-11-22T04:01:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214760510.3390/ijms22147605Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 InfectionWeronika Bielka0Agnieszka Przezak1Andrzej Pawlik2Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandCOVID-19 infection poses an important clinical therapeutic problem, especially in patients with coexistent diseases such as type 2 diabetes. Potential pathogenetic links between COVID-19 and diabetes include inflammation, effects on glucose homeostasis, haemoglobin deoxygenation, altered immune status and activation of the renin-angiotensin-aldosterone system (RAAS). Moreover, drugs often used in the clinical care of diabetes (dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, metformin and insulin) may influence the course of SARS-CoV-2 infection, so it is very important to verify their effectiveness and safety. This review summarises the new advances in diabetes therapy and COVID-19 and provides clinical recommendations that are essential for medical doctors and for patients suffering from type 2 diabetes.https://www.mdpi.com/1422-0067/22/14/7605COVID-19diabetestherapy
spellingShingle Weronika Bielka
Agnieszka Przezak
Andrzej Pawlik
Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
International Journal of Molecular Sciences
COVID-19
diabetes
therapy
title Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
title_full Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
title_fullStr Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
title_full_unstemmed Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
title_short Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
title_sort therapy of type 2 diabetes in patients with sars cov 2 infection
topic COVID-19
diabetes
therapy
url https://www.mdpi.com/1422-0067/22/14/7605
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AT agnieszkaprzezak therapyoftype2diabetesinpatientswithsarscov2infection
AT andrzejpawlik therapyoftype2diabetesinpatientswithsarscov2infection