Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells

Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells

Doxorubicin (DOX) is commonly used in cancer treatment but associated with cardiotoxicity. Pyridoxamine (PM), a vitamin B6 derivative, could be a cardioprotectant. This study investigated the effect of PM on DOX cardiotoxicity and DOX antitumor effectiveness. Sprague Dawley rats were treated intrave...

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Bibliographic Details
Main Authors: Sibren Haesen, Eline Verghote, Ellen Heeren, Esther Wolfs, Dorien Deluyker, Virginie Bito
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
breast cancer
rat mammary tumor cells
doxorubicin
cardiotoxicity
pyridoxamine
Online Access:https://www.mdpi.com/2073-4409/13/2/120

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