Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study
ABSTRACT: Background: Adverse drug events (ADEs) are common complications of clinical care resulting in significant morbidity, mortality, and high clinical expenditure. Population-level estimates of inpatient ADEs are limited in Ethiopia. Objective: This study aimed to assess the incidence, contrib...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Current Therapeutic Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0011393X20300370 |
| _version_ | 1818352463299739648 |
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| author | Tamiru Sahilu, MSc Mestawet Getachew, MSc Tsegaye Melaku, MSc Tadesse Sheleme, MSc |
| author_facet | Tamiru Sahilu, MSc Mestawet Getachew, MSc Tsegaye Melaku, MSc Tadesse Sheleme, MSc |
| author_sort | Tamiru Sahilu, MSc |
| collection | DOAJ |
| description | ABSTRACT: Background: Adverse drug events (ADEs) are common complications of clinical care resulting in significant morbidity, mortality, and high clinical expenditure. Population-level estimates of inpatient ADEs are limited in Ethiopia. Objective: This study aimed to assess the incidence, contributing factors, severity, and preventability of ADEs among hospitalized adult patients at Jimma Medical Center, Ethiopia. Methods: A prospective observational study design was conducted among hospitalized adult patients at tertiary hospital in Ethiopia. A structured data collection tool was prepared from relevant literatures for data collection. Data were analyzed using statistical software. Logistic regression was performed to identify factors contributing to ADE occurrence. P values < 0.05 were considered statistically significant. Results: A total of 319 patients were included with follow-up period of 5667 person-days. About 50.5% were women. The mean (SD) age of patients was 43 (17.6) years. One hundred sixteen ADEs were identified with the incidence of 36.4 (95% CI, 30.1–43.6) per 100 admissions and 20.5 (95% CI, 16.9–24.6) per 1000 person-days. Antituberculosis agents (adjusted odds ratio [aOR] = 2.52; 95% CI, 1.06–5.98; P = 0.036), disease of the circulatory system (aOR = 2.67; 95% CI, 1.46–4.89; P = 0.001), disease of the digestive system (aOR = 2.84; 95% CI, 1.45–5.57; P = 0.002), being on medication during admission (aOR = 3.09; 95% CI, 1.77–5.41; P < 0.001), and hospital stay more than 2 weeks (aOR = 3.93; 95% CI, 1.39–11.12; P = 0.010) were independent predictors of ADE occurrence. Conclusions: One in every 4 patients admitted to the hospital experienced ADEs during their hospital stay. Most ADEs were moderate in severity. About two-thirds of the ADEs identified were deemed probably or definitely preventable. Therefore, it is high time to reinforce large-scale efforts to redesign safer, higher quality health care systems to adequately tackle the problem. |
| first_indexed | 2024-12-13T18:54:02Z |
| format | Article |
| id | doaj.art-6caa6fa41ad34dd98bb78d1991045bad |
| institution | Directory Open Access Journal |
| issn | 0011-393X |
| language | English |
| last_indexed | 2024-12-13T18:54:02Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Therapeutic Research |
| spelling | doaj.art-6caa6fa41ad34dd98bb78d1991045bad2022-12-21T23:34:52ZengElsevierCurrent Therapeutic Research0011-393X2020-01-0193100611Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational StudyTamiru Sahilu, MSc0Mestawet Getachew, MSc1Tsegaye Melaku, MSc2Tadesse Sheleme, MSc3Department of Pharmacy, College of Health Science, Assosa University, Assosa, Ethiopia; Address correspondence to: Tamiru Sahilu, MSc, Department of Pharmacy, College of Health Science, Assosa University, B40, 5220, Assosa, Ethiopia. Fax :+251 57 775 07 84.Department of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, EthiopiaDepartment of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, EthiopiaDepartment of Pharmacy, College of Public Health and Medical Science, Mettu University, Metu Zuria, EthiopiaABSTRACT: Background: Adverse drug events (ADEs) are common complications of clinical care resulting in significant morbidity, mortality, and high clinical expenditure. Population-level estimates of inpatient ADEs are limited in Ethiopia. Objective: This study aimed to assess the incidence, contributing factors, severity, and preventability of ADEs among hospitalized adult patients at Jimma Medical Center, Ethiopia. Methods: A prospective observational study design was conducted among hospitalized adult patients at tertiary hospital in Ethiopia. A structured data collection tool was prepared from relevant literatures for data collection. Data were analyzed using statistical software. Logistic regression was performed to identify factors contributing to ADE occurrence. P values < 0.05 were considered statistically significant. Results: A total of 319 patients were included with follow-up period of 5667 person-days. About 50.5% were women. The mean (SD) age of patients was 43 (17.6) years. One hundred sixteen ADEs were identified with the incidence of 36.4 (95% CI, 30.1–43.6) per 100 admissions and 20.5 (95% CI, 16.9–24.6) per 1000 person-days. Antituberculosis agents (adjusted odds ratio [aOR] = 2.52; 95% CI, 1.06–5.98; P = 0.036), disease of the circulatory system (aOR = 2.67; 95% CI, 1.46–4.89; P = 0.001), disease of the digestive system (aOR = 2.84; 95% CI, 1.45–5.57; P = 0.002), being on medication during admission (aOR = 3.09; 95% CI, 1.77–5.41; P < 0.001), and hospital stay more than 2 weeks (aOR = 3.93; 95% CI, 1.39–11.12; P = 0.010) were independent predictors of ADE occurrence. Conclusions: One in every 4 patients admitted to the hospital experienced ADEs during their hospital stay. Most ADEs were moderate in severity. About two-thirds of the ADEs identified were deemed probably or definitely preventable. Therefore, it is high time to reinforce large-scale efforts to redesign safer, higher quality health care systems to adequately tackle the problem.http://www.sciencedirect.com/science/article/pii/S0011393X20300370Adverse drug eventContributing factorIncidence rateIndependent predictorPatient safetyProspective observational study |
| spellingShingle | Tamiru Sahilu, MSc Mestawet Getachew, MSc Tsegaye Melaku, MSc Tadesse Sheleme, MSc Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study Current Therapeutic Research Adverse drug event Contributing factor Incidence rate Independent predictor Patient safety Prospective observational study |
| title | Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study |
| title_full | Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study |
| title_fullStr | Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study |
| title_full_unstemmed | Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study |
| title_short | Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study |
| title_sort | adverse drug events and contributing factors among hospitalized adult patients at jimma medical center southwest ethiopia a prospective observational study |
| topic | Adverse drug event Contributing factor Incidence rate Independent predictor Patient safety Prospective observational study |
| url | http://www.sciencedirect.com/science/article/pii/S0011393X20300370 |
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