Two New Xanthones from Calophyllum nodusum (Guttiferae)

The air-dried powdered stem bark of Calophyllum nodusum (Guttiferea) collected from Sandakan (Sabah, Malaysia), was extracted sequentially with hexane, chloroform and methanol. The solvents were removed by rotary evaporator to give dark viscous extracts. Detailed and repeated chromatographic separat...

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Main Authors: Gwendoline Cheng Lian Ee, Rusea Go, Nur Kartinee Kassim, Siti Noor Kamilah Muhamad, Khozirah Shaari, Mawardi Rahmani, Nadiah Mad Nasir, Mohd Johadi Iskandar
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/16/11/8973/
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author Gwendoline Cheng Lian Ee
Rusea Go
Nur Kartinee Kassim
Siti Noor Kamilah Muhamad
Khozirah Shaari
Mawardi Rahmani
Nadiah Mad Nasir
Mohd Johadi Iskandar
author_facet Gwendoline Cheng Lian Ee
Rusea Go
Nur Kartinee Kassim
Siti Noor Kamilah Muhamad
Khozirah Shaari
Mawardi Rahmani
Nadiah Mad Nasir
Mohd Johadi Iskandar
author_sort Gwendoline Cheng Lian Ee
collection DOAJ
description The air-dried powdered stem bark of Calophyllum nodusum (Guttiferea) collected from Sandakan (Sabah, Malaysia), was extracted sequentially with hexane, chloroform and methanol. The solvents were removed by rotary evaporator to give dark viscous extracts. Detailed and repeated chromatographic separation of the extracts lead to isolation of two new xanthones, identified as nodusuxanthone (1a) and trapezifolixanthone A (2). Other common terpenoids such as betulinic acid, lupeol, stigmasterol and friedelin were also isolated from the extracts and identified. The structures of the compounds were established by detailed spectral analysis and comparison with previously reported data.
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spelling doaj.art-6caaf45818404ebdb3deca2569bc73a92022-12-22T00:00:30ZengMDPI AGMolecules1420-30492011-10-0116118973898010.3390/molecules16118973Two New Xanthones from Calophyllum nodusum (Guttiferae)Gwendoline Cheng Lian EeRusea GoNur Kartinee KassimSiti Noor Kamilah MuhamadKhozirah ShaariMawardi RahmaniNadiah Mad NasirMohd Johadi IskandarThe air-dried powdered stem bark of Calophyllum nodusum (Guttiferea) collected from Sandakan (Sabah, Malaysia), was extracted sequentially with hexane, chloroform and methanol. The solvents were removed by rotary evaporator to give dark viscous extracts. Detailed and repeated chromatographic separation of the extracts lead to isolation of two new xanthones, identified as nodusuxanthone (1a) and trapezifolixanthone A (2). Other common terpenoids such as betulinic acid, lupeol, stigmasterol and friedelin were also isolated from the extracts and identified. The structures of the compounds were established by detailed spectral analysis and comparison with previously reported data.http://www.mdpi.com/1420-3049/16/11/8973/Calophyllum nodusumnodusuxanthonetrapezifolixanthone Alupeolstigmasterol
spellingShingle Gwendoline Cheng Lian Ee
Rusea Go
Nur Kartinee Kassim
Siti Noor Kamilah Muhamad
Khozirah Shaari
Mawardi Rahmani
Nadiah Mad Nasir
Mohd Johadi Iskandar
Two New Xanthones from Calophyllum nodusum (Guttiferae)
Molecules
Calophyllum nodusum
nodusuxanthone
trapezifolixanthone A
lupeol
stigmasterol
title Two New Xanthones from Calophyllum nodusum (Guttiferae)
title_full Two New Xanthones from Calophyllum nodusum (Guttiferae)
title_fullStr Two New Xanthones from Calophyllum nodusum (Guttiferae)
title_full_unstemmed Two New Xanthones from Calophyllum nodusum (Guttiferae)
title_short Two New Xanthones from Calophyllum nodusum (Guttiferae)
title_sort two new xanthones from calophyllum nodusum guttiferae
topic Calophyllum nodusum
nodusuxanthone
trapezifolixanthone A
lupeol
stigmasterol
url http://www.mdpi.com/1420-3049/16/11/8973/
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