Binding of NAD<sup>+</sup>-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A <italic toggle="yes">Streptococcus</italic>

Binding of NAD<sup>+</sup>-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A <italic toggle="yes">Streptococcus</italic>

ABSTRACT The globally dominant, invasive M1T1 strain of group A Streptococcus (GAS) harbors polymorphisms in the promoter region of an operon that contains the genes encoding streptolysin O (SLO) and NAD+-glycohydrolase (NADase), resulting in high-level expression of these toxins. While both toxins...

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Bibliographic Details
Main Authors: Jorge J. Velarde, Maghnus O’Seaghdha, Buket Baddal, Benedicte Bastiat-Sempe, Michael R. Wessels
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
NAD+-glycohydrolase
Streptococcus pyogenes
cholesterol-dependent cytolysin
pore-forming toxins
streptolysin O
Online Access:https://journals.asm.org/doi/10.1128/mBio.01382-17

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