Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients
Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%; therefore, non-invasive biomarkers such as measurable circulating proteins for early detection and prognosis are crucial. Insulin-like growth factor-1 (IGF-1) is involved in the regulation of cell proliferation and...
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2023-11-01
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author | Maryam H. Alrashid Ahmad E. Al-Serri Rubina F. Hussain Suzanne A. Al-Bustan Jasem Al-Barrak |
author_facet | Maryam H. Alrashid Ahmad E. Al-Serri Rubina F. Hussain Suzanne A. Al-Bustan Jasem Al-Barrak |
author_sort | Maryam H. Alrashid |
collection | DOAJ |
description | Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%; therefore, non-invasive biomarkers such as measurable circulating proteins for early detection and prognosis are crucial. Insulin-like growth factor-1 (IGF-1) is involved in the regulation of cell proliferation and apoptosis. IGF binding proteins (IGFBPs) bind and inhibit the activity of IGF-1. It was inconsistently reported that high IGF-1 and IGFBP-2 and low IGFBP-3 circulating levels are associated with high cancer risk, poor prognosis, and tumor metastasis in several cancers. A total of 175 patients with CRC and 429 controls were enrolled in this study. We genotyped for IGF-1 rs35767 and rs6214 gene polymorphisms and assessed their association with circulating levels of IGF-1 and/or the risk for CRC. We also determined plasma levels of IGF-1, IGFBP-2, and IGFBP-3. Neither rs35767 nor rs2614 were associated with cancer risk or IGF-1 levels in our study cohort. IGF-1 and IGFBP-3 levels were higher in controls than in patients, whereas IGFBP-2 was higher in patients than in controls. Only IGFBP-2 was associated with increased tumor grade but not stage. Therefore, IGF-1, IGFBP-2, and IGFBP-3 may be useful as early detection and prognostic biomarkers in CRC. |
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language | English |
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spelling | doaj.art-6cb2011d09294b82a89791d80056d37e2023-12-22T13:54:51ZengMDPI AGBiomedicines2227-90592023-11-011112316610.3390/biomedicines11123166Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer PatientsMaryam H. Alrashid0Ahmad E. Al-Serri1Rubina F. Hussain2Suzanne A. Al-Bustan3Jasem Al-Barrak4Department of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait City 13060, KuwaitHuman Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait City 13060, KuwaitDepartment of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait City 13060, KuwaitDepartment of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait City 13060, KuwaitKuwait Cancer Control Center, Kuwait City 70030, KuwaitEarly detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%; therefore, non-invasive biomarkers such as measurable circulating proteins for early detection and prognosis are crucial. Insulin-like growth factor-1 (IGF-1) is involved in the regulation of cell proliferation and apoptosis. IGF binding proteins (IGFBPs) bind and inhibit the activity of IGF-1. It was inconsistently reported that high IGF-1 and IGFBP-2 and low IGFBP-3 circulating levels are associated with high cancer risk, poor prognosis, and tumor metastasis in several cancers. A total of 175 patients with CRC and 429 controls were enrolled in this study. We genotyped for IGF-1 rs35767 and rs6214 gene polymorphisms and assessed their association with circulating levels of IGF-1 and/or the risk for CRC. We also determined plasma levels of IGF-1, IGFBP-2, and IGFBP-3. Neither rs35767 nor rs2614 were associated with cancer risk or IGF-1 levels in our study cohort. IGF-1 and IGFBP-3 levels were higher in controls than in patients, whereas IGFBP-2 was higher in patients than in controls. Only IGFBP-2 was associated with increased tumor grade but not stage. Therefore, IGF-1, IGFBP-2, and IGFBP-3 may be useful as early detection and prognostic biomarkers in CRC.https://www.mdpi.com/2227-9059/11/12/3166insulin-like growth factor-1colorectal cancerbiomarkersgene polymorphism |
spellingShingle | Maryam H. Alrashid Ahmad E. Al-Serri Rubina F. Hussain Suzanne A. Al-Bustan Jasem Al-Barrak Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients Biomedicines insulin-like growth factor-1 colorectal cancer biomarkers gene polymorphism |
title | Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients |
title_full | Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients |
title_fullStr | Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients |
title_full_unstemmed | Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients |
title_short | Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients |
title_sort | association study of igf 1 rs35767 and rs6214 gene polymorphisms with cancer susceptibility and circulating levels of igf 1 igfbp 2 and igfbp 3 in colorectal cancer patients |
topic | insulin-like growth factor-1 colorectal cancer biomarkers gene polymorphism |
url | https://www.mdpi.com/2227-9059/11/12/3166 |
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