New blocking antibodies impede adhesion, migration and survival of ovarian cancer cells, highlighting MFGE8 as a potential therapeutic target of human ovarian carcinoma.

New blocking antibodies impede adhesion, migration and survival of ovarian cancer cells, highlighting MFGE8 as a potential therapeutic target of human ovarian carcinoma.

Milk Fat Globule--EGF--factor VIII (MFGE8), also called lactadherin, is a secreted protein, which binds extracellularly to phosphatidylserine and to αvβ3 and αvβ5 integrins. On human and mouse cells expressing these integrins, such as endothelial cells, phagocytes and some tumors, MFGE8/lactadherin...

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Main Authors: Lorenzo Tibaldi, Shirley Leyman, André Nicolas, Sofie Notebaert, Melissa Dewulf, Thu Hoa Ngo, Claudia Zuany-Amorim, Nathalie Amzallag, Isabelle Bernard-Pierrot, Xavier Sastre-Garau, Clotilde Théry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745384?pdf=render

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