Noninvasive vaccination against infectious diseases
The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-07-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1461296 |
| _version_ | 1797677478477561856 |
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| author | Zhichao Zheng Diana Diaz-Arévalo Hongbing Guan Mingtao Zeng |
| author_facet | Zhichao Zheng Diana Diaz-Arévalo Hongbing Guan Mingtao Zeng |
| author_sort | Zhichao Zheng |
| collection | DOAJ |
| description | The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future. |
| first_indexed | 2024-03-11T22:45:43Z |
| format | Article |
| id | doaj.art-6cb2eccb5cbb4d66ab504fff51d386a7 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:43Z |
| publishDate | 2018-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-6cb2eccb5cbb4d66ab504fff51d386a72023-09-22T08:38:21ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-07-011471717173310.1080/21645515.2018.14612961461296Noninvasive vaccination against infectious diseasesZhichao Zheng0Diana Diaz-Arévalo1Hongbing Guan2Mingtao Zeng3Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical UniversityFundación Instituto de Inmunología de Colombia-FIDIC, Faculty of Agricultural Sciences, Universidad de Ciencias Aplicadas y Ambientales U.D.C.A, School of Medicine and Health Sciences, Universidad del RosarioGuangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical UniversityGuangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical UniversityThe development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effective in humans there are some issues that should be considered, such as the adjuvant, the route of vaccination, and the antigen-carrier system. While almost all licensed vaccines are injected such that inoculation is by far the most commonly used method, injection has several potential disadvantages, including pain, cross contamination, needlestick injury, under- or overdosing, and increased cost. It is also problematic for patients from rural areas of developing countries, who must travel to a hospital for vaccine administration. Noninvasive immunizations, including oral, intranasal, and transcutaneous administration of vaccines, can reduce or eliminate pain, reduce the cost of vaccinations, and increase their safety. Several preclinical and clinical studies as well as experience with licensed vaccines have demonstrated that noninvasive vaccine immunization activates cellular and humoral immunity, which protect against pathogen infections. Here we review the development of noninvasive immunization with vaccines based on live attenuated virus, recombinant adenovirus, inactivated virus, viral subunits, virus-like particles, DNA, RNA, and antigen expression in rice in preclinical and clinical studies. We predict that noninvasive vaccine administration will be more widely applied in the clinic in the near future.http://dx.doi.org/10.1080/21645515.2018.1461296bacteriaclinical trialinfectious diseaseintranasalmicroneedlenoninvasiveoraltranscutaneousvaccinevirus |
| spellingShingle | Zhichao Zheng Diana Diaz-Arévalo Hongbing Guan Mingtao Zeng Noninvasive vaccination against infectious diseases Human Vaccines & Immunotherapeutics bacteria clinical trial infectious disease intranasal microneedle noninvasive oral transcutaneous vaccine virus |
| title | Noninvasive vaccination against infectious diseases |
| title_full | Noninvasive vaccination against infectious diseases |
| title_fullStr | Noninvasive vaccination against infectious diseases |
| title_full_unstemmed | Noninvasive vaccination against infectious diseases |
| title_short | Noninvasive vaccination against infectious diseases |
| title_sort | noninvasive vaccination against infectious diseases |
| topic | bacteria clinical trial infectious disease intranasal microneedle noninvasive oral transcutaneous vaccine virus |
| url | http://dx.doi.org/10.1080/21645515.2018.1461296 |
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