Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries
Introduction: Anaemia is associated with increased post-operative morbidity and mortality. We retrospectively assess the relationship between preoperative anaemia and in-hospital mortality in valvular cardiac surgical population. Materials and Methods: Data from consecutive adult patients who underw...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Annals of Cardiac Anaesthesia |
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| Online Access: | http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=3;spage=373;epage=379;aulast=Joshi |
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| author | Shreedhar S Joshi Antony George Dhananjaya Manasa Hemalatha M.R. Savita Prasad T.H. Krishna A M Jagadeesh |
| author_facet | Shreedhar S Joshi Antony George Dhananjaya Manasa Hemalatha M.R. Savita Prasad T.H. Krishna A M Jagadeesh |
| author_sort | Shreedhar S Joshi |
| collection | DOAJ |
| description | Introduction: Anaemia is associated with increased post-operative morbidity and mortality. We retrospectively assess the relationship between preoperative anaemia and in-hospital mortality in valvular cardiac surgical population. Materials and Methods: Data from consecutive adult patients who underwent valvular repair/ replacement at our institute from January 2010 to April 2014 were collected from hospital records. Anaemia was defined according to WHO criteria (hemoglobin <13g/dl for males and <12g/dl for females). 1:1 matching was done for anemic and non-anemic patients based on propensity for potentially confounding variables. Logistic regression was used to evaluate the relationship between anaemia and in-hospital mortality. MatchIt package for R software was used for propensity matching and SPSS 16.0.0 was used for statistical analysis. Results: 2449 patients undergoing valvular surgery with or without coronary artery grafting were included. Anaemia was present in 37.1% (33.91% among males & 40.88% among females). Unadjusted OR for mortality was 1.6 in anemic group (95% Confidence Interval [95% CI] - 1.041-2.570; p=0.033). 1:1 matching was done on the basis of propensity score for anaemia (866 pairs). Balancing was confirmed using standardized differences. Anaemia had an OR of 1.8 for mortality (95% CI- 1.042 to 3.094, P=0.035). Hematocrit of < 20 on bypass was associated with higher mortality. Conclusion: Preoperative anaemia is an independent risk factor associated with in-hospital mortality in patients undergoing valvular heart surgery. |
| first_indexed | 2024-12-11T22:55:25Z |
| format | Article |
| id | doaj.art-6cb306f99589440cb76a9ac29cc3b6d7 |
| institution | Directory Open Access Journal |
| issn | 0971-9784 |
| language | English |
| last_indexed | 2024-12-11T22:55:25Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Cardiac Anaesthesia |
| spelling | doaj.art-6cb306f99589440cb76a9ac29cc3b6d72022-12-22T00:47:16ZengWolters Kluwer Medknow PublicationsAnnals of Cardiac Anaesthesia0971-97842015-01-0118337337910.4103/0971-9784.159808Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeriesShreedhar S JoshiAntony GeorgeDhananjaya ManasaHemalatha M.R. SavitaPrasad T.H. KrishnaA M JagadeeshIntroduction: Anaemia is associated with increased post-operative morbidity and mortality. We retrospectively assess the relationship between preoperative anaemia and in-hospital mortality in valvular cardiac surgical population. Materials and Methods: Data from consecutive adult patients who underwent valvular repair/ replacement at our institute from January 2010 to April 2014 were collected from hospital records. Anaemia was defined according to WHO criteria (hemoglobin <13g/dl for males and <12g/dl for females). 1:1 matching was done for anemic and non-anemic patients based on propensity for potentially confounding variables. Logistic regression was used to evaluate the relationship between anaemia and in-hospital mortality. MatchIt package for R software was used for propensity matching and SPSS 16.0.0 was used for statistical analysis. Results: 2449 patients undergoing valvular surgery with or without coronary artery grafting were included. Anaemia was present in 37.1% (33.91% among males & 40.88% among females). Unadjusted OR for mortality was 1.6 in anemic group (95% Confidence Interval [95% CI] - 1.041-2.570; p=0.033). 1:1 matching was done on the basis of propensity score for anaemia (866 pairs). Balancing was confirmed using standardized differences. Anaemia had an OR of 1.8 for mortality (95% CI- 1.042 to 3.094, P=0.035). Hematocrit of < 20 on bypass was associated with higher mortality. Conclusion: Preoperative anaemia is an independent risk factor associated with in-hospital mortality in patients undergoing valvular heart surgery.http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=3;spage=373;epage=379;aulast=JoshiPreoperative Anemia and Cardiac Surgery; Propensity Matching; Valvular Heart Disease |
| spellingShingle | Shreedhar S Joshi Antony George Dhananjaya Manasa Hemalatha M.R. Savita Prasad T.H. Krishna A M Jagadeesh Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries Annals of Cardiac Anaesthesia Preoperative Anemia and Cardiac Surgery; Propensity Matching; Valvular Heart Disease |
| title | Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries |
| title_full | Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries |
| title_fullStr | Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries |
| title_full_unstemmed | Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries |
| title_short | Propensity-matched analysis of association between preoperative anemia and in-hospital mortality in cardiac surgical patients undergoing valvular heart surgeries |
| title_sort | propensity matched analysis of association between preoperative anemia and in hospital mortality in cardiac surgical patients undergoing valvular heart surgeries |
| topic | Preoperative Anemia and Cardiac Surgery; Propensity Matching; Valvular Heart Disease |
| url | http://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=3;spage=373;epage=379;aulast=Joshi |
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