Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics
Chagas disease, caused by <i>Trypanosoma cruzi</i> and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines. Here, we assessed the impa...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/2079-7737/12/9/1235 |
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| author | Edem Fiatsonu Aniruddha Deka Martial L. Ndeffo-Mbah |
| author_facet | Edem Fiatsonu Aniruddha Deka Martial L. Ndeffo-Mbah |
| author_sort | Edem Fiatsonu |
| collection | DOAJ |
| description | Chagas disease, caused by <i>Trypanosoma cruzi</i> and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines. Here, we assessed the impact of dog treatment on <i>T. cruzi</i> transmission. We developed a mathematical model of <i>T. cruzi</i> transmission among triatomines, dogs, humans, and rodents. We used the model to evaluate the impact of dog treatment regimens on <i>T. cruzi</i> transmission dynamics to determine their effectiveness in reducing <i>T. cruzi</i> infection among hosts. We show that a 3-month treatment regimen may reduce <i>T. cruzi</i> incidence among humans by 59–80% in a high transmission setting, and 26–82% in a low transmission setting. An annual treatment may reduce incidence among humans by 49–74% in a high transmission setting, and by 11–76% in a low transmission setting. However, dog treatment may substantially increase <i>T. cruzi</i> prevalence among dogs if dog consumption of dead triatomines increases. Our model indicates that dog treatment may reduce <i>T. cruzi</i> infections among humans, but it may increase infections in dogs. Therefore, a holistic approach targeting different hosts is necessary for Chagas elimination. |
| first_indexed | 2024-03-10T23:01:26Z |
| format | Article |
| id | doaj.art-6cb3cb4821774f1eb1c15a2c2c8e87a3 |
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| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T23:01:26Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-6cb3cb4821774f1eb1c15a2c2c8e87a32023-11-19T09:38:55ZengMDPI AGBiology2079-77372023-09-01129123510.3390/biology12091235Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the TropicsEdem Fiatsonu0Aniruddha Deka1Martial L. Ndeffo-Mbah2Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77845, USADepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77845, USADepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77845, USAChagas disease, caused by <i>Trypanosoma cruzi</i> and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines. Here, we assessed the impact of dog treatment on <i>T. cruzi</i> transmission. We developed a mathematical model of <i>T. cruzi</i> transmission among triatomines, dogs, humans, and rodents. We used the model to evaluate the impact of dog treatment regimens on <i>T. cruzi</i> transmission dynamics to determine their effectiveness in reducing <i>T. cruzi</i> infection among hosts. We show that a 3-month treatment regimen may reduce <i>T. cruzi</i> incidence among humans by 59–80% in a high transmission setting, and 26–82% in a low transmission setting. An annual treatment may reduce incidence among humans by 49–74% in a high transmission setting, and by 11–76% in a low transmission setting. However, dog treatment may substantially increase <i>T. cruzi</i> prevalence among dogs if dog consumption of dead triatomines increases. Our model indicates that dog treatment may reduce <i>T. cruzi</i> infections among humans, but it may increase infections in dogs. Therefore, a holistic approach targeting different hosts is necessary for Chagas elimination.https://www.mdpi.com/2079-7737/12/9/1235<i>Trypanosoma cruzi</i>chagas diseasesystemic insecticideRoss–MacDonald model |
| spellingShingle | Edem Fiatsonu Aniruddha Deka Martial L. Ndeffo-Mbah Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics Biology <i>Trypanosoma cruzi</i> chagas disease systemic insecticide Ross–MacDonald model |
| title | Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics |
| title_full | Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics |
| title_fullStr | Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics |
| title_full_unstemmed | Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics |
| title_short | Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics |
| title_sort | effectiveness of systemic insecticide dog treatment for the control of chagas disease in the tropics |
| topic | <i>Trypanosoma cruzi</i> chagas disease systemic insecticide Ross–MacDonald model |
| url | https://www.mdpi.com/2079-7737/12/9/1235 |
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