Tumor Microenvironment on a Chip: The Progress and Future Perspective
Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/4/3/64 |
| _version_ | 1827887847333429248 |
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| author | Jungho Ahn Yoshitaka J. Sei Noo Li Jeon YongTae Kim |
| author_facet | Jungho Ahn Yoshitaka J. Sei Noo Li Jeon YongTae Kim |
| author_sort | Jungho Ahn |
| collection | DOAJ |
| description | Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications. |
| first_indexed | 2024-03-12T20:25:25Z |
| format | Article |
| id | doaj.art-6cb53745e2674eeda5d10ce5f24b4453 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T20:25:25Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-6cb53745e2674eeda5d10ce5f24b44532023-08-02T00:34:39ZengMDPI AGBioengineering2306-53542017-07-01436410.3390/bioengineering4030064bioengineering4030064Tumor Microenvironment on a Chip: The Progress and Future PerspectiveJungho Ahn0Yoshitaka J. Sei1Noo Li Jeon2YongTae Kim3George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USAGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USASchool of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, KoreaGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USATumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.https://www.mdpi.com/2306-5354/4/3/64organ-on-a-chipmicrofluidicsin vitro disease modelstumor microenvironmentdrug screeningnanomedicine |
| spellingShingle | Jungho Ahn Yoshitaka J. Sei Noo Li Jeon YongTae Kim Tumor Microenvironment on a Chip: The Progress and Future Perspective Bioengineering organ-on-a-chip microfluidics in vitro disease models tumor microenvironment drug screening nanomedicine |
| title | Tumor Microenvironment on a Chip: The Progress and Future Perspective |
| title_full | Tumor Microenvironment on a Chip: The Progress and Future Perspective |
| title_fullStr | Tumor Microenvironment on a Chip: The Progress and Future Perspective |
| title_full_unstemmed | Tumor Microenvironment on a Chip: The Progress and Future Perspective |
| title_short | Tumor Microenvironment on a Chip: The Progress and Future Perspective |
| title_sort | tumor microenvironment on a chip the progress and future perspective |
| topic | organ-on-a-chip microfluidics in vitro disease models tumor microenvironment drug screening nanomedicine |
| url | https://www.mdpi.com/2306-5354/4/3/64 |
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