Standardized Diagnostics Including PET-CT Imaging, Bilateral Tonsillectomy and Neck Dissection Followed by Risk-Adapted Post-Operative Treatment Favoring Radio-Chemotherapy Improve Survival of Neck Squamous Cell Carcinoma of Unknown Primary Patients

Standardized Diagnostics Including PET-CT Imaging, Bilateral Tonsillectomy and Neck Dissection Followed by Risk-Adapted Post-Operative Treatment Favoring Radio-Chemotherapy Improve Survival of Neck Squamous Cell Carcinoma of Unknown Primary Patients

BackgroundAbout five to 10% of cancers in the head and neck region are neck squamous cell carcinoma of unknown primary (NSCCUP). Their diagnosis and treatment are challenging given the risk of missing occult tumors and potential relapse. Recently, we described human papillomavirus (HPV)-related NSCC...

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Bibliographic Details
Main Authors: Gunnar Wichmann, Maria Willner, Thomas Kuhnt, Regine Kluge, Tanja Gradistanac, Theresa Wald, Sandra Fest, Florian Lordick, Andreas Dietz, Susanne Wiegand, Veit Zebralla
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
cancer of unknown primary (CUP)
neck dissection (ND)
extracapsular extension of neck nodes (ECE)
cisplatin-based postoperative radio-chemotherapy
outcome research
head and neck cancer (HNC)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.682088/full

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