Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy
As an important second messenger, the calcium ion (Ca2+) plays a vital role in normal brain function and in the pathophysiological process of different neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and epilepsy. Ca2+ takes part in the re...
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MDPI AG
2018-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/9/2735 |
| _version_ | 1811337523883933696 |
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| author | Jie-Hua Xu Feng-Ru Tang |
| author_facet | Jie-Hua Xu Feng-Ru Tang |
| author_sort | Jie-Hua Xu |
| collection | DOAJ |
| description | As an important second messenger, the calcium ion (Ca2+) plays a vital role in normal brain function and in the pathophysiological process of different neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and epilepsy. Ca2+ takes part in the regulation of neuronal excitability, and the imbalance of intracellular Ca2+ is a trigger factor for the occurrence of epilepsy. Several anti-epileptic drugs target voltage-dependent calcium channels (VDCCs). Intracellular Ca2+ levels are mainly controlled by VDCCs located in the plasma membrane, the calcium-binding proteins (CBPs) inside the cytoplasm, calcium channels located on the intracellular calcium store (particular the endoplasmic reticulum/sarcoplasmic reticulum), and the Ca2+-pumps located in the plasma membrane and intracellular calcium store. So far, while many studies have established the relationship between calcium control factors and epilepsy, the mechanism of various Ca2+ regulatory factors in epileptogenesis is still unknown. In this paper, we reviewed the function, distribution, and alteration of VDCCs and CBPs in the central nervous system in the pathological process of epilepsy. The interaction of VDCCs with CBPs in the pathological process of epilepsy was also summarized. We hope this review can provide some clues for better understanding the mechanism of epileptogenesis, and for the development of new anti-epileptic drugs targeting on VDCCs and CBPs. |
| first_indexed | 2024-04-13T17:56:14Z |
| format | Article |
| id | doaj.art-6cb616ee59b44e038faedb34bdecb22d |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T17:56:14Z |
| publishDate | 2018-09-01 |
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| spelling | doaj.art-6cb616ee59b44e038faedb34bdecb22d2022-12-22T02:36:29ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-09-01199273510.3390/ijms19092735ijms19092735Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of EpilepsyJie-Hua Xu0Feng-Ru Tang1Epilepsy Research Laboratory of Human Anatomy and Histoembryology Department, Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Xi’an Jiaotong University School of Basic Medical Sciences, Ministry of Education, Xi’an 710061, ChinaRadiation Physiology Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, 1 CREATE Way #04-01, CREATE Tower, Singapore 138602, SingaporeAs an important second messenger, the calcium ion (Ca2+) plays a vital role in normal brain function and in the pathophysiological process of different neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and epilepsy. Ca2+ takes part in the regulation of neuronal excitability, and the imbalance of intracellular Ca2+ is a trigger factor for the occurrence of epilepsy. Several anti-epileptic drugs target voltage-dependent calcium channels (VDCCs). Intracellular Ca2+ levels are mainly controlled by VDCCs located in the plasma membrane, the calcium-binding proteins (CBPs) inside the cytoplasm, calcium channels located on the intracellular calcium store (particular the endoplasmic reticulum/sarcoplasmic reticulum), and the Ca2+-pumps located in the plasma membrane and intracellular calcium store. So far, while many studies have established the relationship between calcium control factors and epilepsy, the mechanism of various Ca2+ regulatory factors in epileptogenesis is still unknown. In this paper, we reviewed the function, distribution, and alteration of VDCCs and CBPs in the central nervous system in the pathological process of epilepsy. The interaction of VDCCs with CBPs in the pathological process of epilepsy was also summarized. We hope this review can provide some clues for better understanding the mechanism of epileptogenesis, and for the development of new anti-epileptic drugs targeting on VDCCs and CBPs.http://www.mdpi.com/1422-0067/19/9/2735calcium binding proteins (CBPs)voltage-dependent calcium channels (VDCCs)epilepsy |
| spellingShingle | Jie-Hua Xu Feng-Ru Tang Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy International Journal of Molecular Sciences calcium binding proteins (CBPs) voltage-dependent calcium channels (VDCCs) epilepsy |
| title | Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy |
| title_full | Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy |
| title_fullStr | Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy |
| title_full_unstemmed | Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy |
| title_short | Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy |
| title_sort | voltage dependent calcium channels calcium binding proteins and their interaction in the pathological process of epilepsy |
| topic | calcium binding proteins (CBPs) voltage-dependent calcium channels (VDCCs) epilepsy |
| url | http://www.mdpi.com/1422-0067/19/9/2735 |
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