Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

Microglia are dependent on signaling through the colony stimulating factor-1 receptor (CSF-1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while blocking CSF-1R can lead to rapid microglia cell death. CSF-1R has two ligands, the growth factors colony stimulating fa...

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Bibliographic Details
Main Authors:	Douglas G. Walker, Tiffany M. Tang, Lih-Fen Lue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Series:	Frontiers in Aging Neuroscience
Subjects:	neuroinflammation human microglia neuropathology quantitative polymerase chain reaction RNA-sequencing activation phenotype
Online Access:	http://journal.frontiersin.org/article/10.3389/fnagi.2017.00244/full

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