Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering

Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering

Abstract We present a generically applicable approach to determine an extensive set of size-dependent critical quality attributes inside nanoparticulate pharmaceutical products. By coupling asymmetrical-flow field-flow fractionation (AF4) measurements directly in-line with solution small angle X-ray...

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Bibliographic Details
Main Authors: Melissa A. Graewert, Christoph Wilhelmy, Tijana Bacic, Jens Schumacher, Clement Blanchet, Florian Meier, Roland Drexel, Roland Welz, Bastian Kolb, Kim Bartels, Thomas Nawroth, Thorsten Klein, Dmitri Svergun, Peter Langguth, Heinrich Haas
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42274-z

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