Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene

Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene

Central obesity is genetically complex, and its exponential increase in the last decades have made it a critical public health issue. The Lyon Hypertensive (LH) rat is a well-characterized hypertensive model that also exhibits spontaneous and profound differences in body weight and adiposity, relati...

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Bibliographic Details
Main Authors: Karen C. Clark, Valerie A. Wagner, Katie L. Holl, John J. Reho, Monika Tutaj, Jennifer R. Smith, Melinda R. Dwinell, Justin L. Grobe, Anne E. Kwitek
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Genetics
Subjects:
congenic rat
QTL mapping
rat model
body weight
metabolism
fat distribution
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.903971/full

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