Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications
In the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun na...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/11/2/199 |
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| author | Arputharaj Joseph Nathanael Tae Hwan Oh |
| author_facet | Arputharaj Joseph Nathanael Tae Hwan Oh |
| author_sort | Arputharaj Joseph Nathanael |
| collection | DOAJ |
| description | In the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun nanofibers for different biomedical applications. Various biopolymers possess good biocompatibility and biodegradability and are nontoxic in nature. Modification of these biopolymers can enhance or elicit certain properties. One technique of modification is the incorporation of certain inorganic ions or components that can enhance its specific functional characteristics such as mineralization, osseointegration, and bioactivity. Incidentally, calcium phosphate (CaP) materials have proven to be suitable and versatile for biopolymer incorporation and exploration because of their inherent bioactivity and being key mineral constituents of bone and teeth. The addition of CaP materials to polymers enhances cell infiltration, differentiation, and biomineralization. We aim to provide a broad overview of CaP material (particularly hydroxyapatite (HA))-incorporated electrospun nanocomposite fibers and their possible applications in tissue engineering. Some key polymer/HA composites were discussed in detail, and a brief discussion on other polymer/HA composites was also provided. Finally, we discussed the future perspectives of this interesting and emerging composite material fabricated via electrospinning. |
| first_indexed | 2024-03-09T00:45:40Z |
| format | Article |
| id | doaj.art-6cbd9047471647359532f2046b8f58a5 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-09T00:45:40Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
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| series | Crystals |
| spelling | doaj.art-6cbd9047471647359532f2046b8f58a52023-12-11T17:30:37ZengMDPI AGCrystals2073-43522021-02-0111219910.3390/cryst11020199Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering ApplicationsArputharaj Joseph Nathanael0Tae Hwan Oh1Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore 632014, IndiaSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, KoreaIn the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun nanofibers for different biomedical applications. Various biopolymers possess good biocompatibility and biodegradability and are nontoxic in nature. Modification of these biopolymers can enhance or elicit certain properties. One technique of modification is the incorporation of certain inorganic ions or components that can enhance its specific functional characteristics such as mineralization, osseointegration, and bioactivity. Incidentally, calcium phosphate (CaP) materials have proven to be suitable and versatile for biopolymer incorporation and exploration because of their inherent bioactivity and being key mineral constituents of bone and teeth. The addition of CaP materials to polymers enhances cell infiltration, differentiation, and biomineralization. We aim to provide a broad overview of CaP material (particularly hydroxyapatite (HA))-incorporated electrospun nanocomposite fibers and their possible applications in tissue engineering. Some key polymer/HA composites were discussed in detail, and a brief discussion on other polymer/HA composites was also provided. Finally, we discussed the future perspectives of this interesting and emerging composite material fabricated via electrospinning.https://www.mdpi.com/2073-4352/11/2/199hydroxyapatitecalcium phosphateelectrospinningbiocompatibilitytissue engineeringwound healing |
| spellingShingle | Arputharaj Joseph Nathanael Tae Hwan Oh Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications Crystals hydroxyapatite calcium phosphate electrospinning biocompatibility tissue engineering wound healing |
| title | Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications |
| title_full | Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications |
| title_fullStr | Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications |
| title_full_unstemmed | Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications |
| title_short | Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications |
| title_sort | encapsulation of calcium phosphates on electrospun nanofibers for tissue engineering applications |
| topic | hydroxyapatite calcium phosphate electrospinning biocompatibility tissue engineering wound healing |
| url | https://www.mdpi.com/2073-4352/11/2/199 |
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