Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin?
In the last decade, a lot has been done in elucidating the sequence of events that occur at the nascent double strand DNA break. Nevertheless, the overall structure formed by the DNA damage response factors around the break site, the repair focus, remains poorly understood. Although most of the data...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00139/full |
| _version_ | 1818265355028529152 |
|---|---|
| author | Velibor eSavic Velibor eSavic |
| author_facet | Velibor eSavic Velibor eSavic |
| author_sort | Velibor eSavic |
| collection | DOAJ |
| description | In the last decade, a lot has been done in elucidating the sequence of events that occur at the nascent double strand DNA break. Nevertheless, the overall structure formed by the DNA damage response factors around the break site, the repair focus, remains poorly understood. Although most of the data presented so far only address events that occur in chromatin in cis around the break, there are strong indications that in mammalian systems it may also occur in trans, analogous to the recent findings showing this if budding yeast. There have been attempts to address the issue but the final proof is still missing due to lack of a proper experimental system. If found to be true, the spatial distribution of DDR factors would have a major impact on the neighbouring chromatin both in cis and in trans, significantly affecting local chromatin function; gene transcription and potentially other functions. |
| first_indexed | 2024-12-12T19:49:29Z |
| format | Article |
| id | doaj.art-6cbe63da0bf047fe96cbb62d65c3ce5d |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T19:49:29Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6cbe63da0bf047fe96cbb62d65c3ce5d2022-12-22T00:14:01ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-07-01410.3389/fgene.2013.0013954389Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin?Velibor eSavic0Velibor eSavic1University of SussexUniversity of SussexIn the last decade, a lot has been done in elucidating the sequence of events that occur at the nascent double strand DNA break. Nevertheless, the overall structure formed by the DNA damage response factors around the break site, the repair focus, remains poorly understood. Although most of the data presented so far only address events that occur in chromatin in cis around the break, there are strong indications that in mammalian systems it may also occur in trans, analogous to the recent findings showing this if budding yeast. There have been attempts to address the issue but the final proof is still missing due to lack of a proper experimental system. If found to be true, the spatial distribution of DDR factors would have a major impact on the neighbouring chromatin both in cis and in trans, significantly affecting local chromatin function; gene transcription and potentially other functions.http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00139/fullDNA damage responseHistone ModificationsATMChromatin structureH2AXRNF168 |
| spellingShingle | Velibor eSavic Velibor eSavic Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? Frontiers in Genetics DNA damage response Histone Modifications ATM Chromatin structure H2AX RNF168 |
| title | Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? |
| title_full | Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? |
| title_fullStr | Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? |
| title_full_unstemmed | Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? |
| title_short | Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin? |
| title_sort | do chromatin changes around a nascent double strand dna break spread spherically into linearly non adjacent chromatin |
| topic | DNA damage response Histone Modifications ATM Chromatin structure H2AX RNF168 |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00139/full |
| work_keys_str_mv | AT veliboresavic dochromatinchangesaroundanascentdoublestranddnabreakspreadsphericallyintolinearlynonadjacentchromatin AT veliboresavic dochromatinchangesaroundanascentdoublestranddnabreakspreadsphericallyintolinearlynonadjacentchromatin |