Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy
In the past few decades, the combination of proteins and small-molecule drugs has made tremendous progress in cancer treatment, but it is still not satisfactory. Because there are great differences in molecular weight, water solubility, stability, pharmacokinetics, biodistribution, and the ways of r...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.994655/full |
| _version_ | 1828419875450650624 |
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| author | Zhihong Cheng Zhihong Cheng Yongshuang Li Duoyi Zhao Wei Zhao Meng Wu Weilin Zhang Yan Cui Peng Zhang Zhiyu Zhang |
| author_facet | Zhihong Cheng Zhihong Cheng Yongshuang Li Duoyi Zhao Wei Zhao Meng Wu Weilin Zhang Yan Cui Peng Zhang Zhiyu Zhang |
| author_sort | Zhihong Cheng |
| collection | DOAJ |
| description | In the past few decades, the combination of proteins and small-molecule drugs has made tremendous progress in cancer treatment, but it is still not satisfactory. Because there are great differences in molecular weight, water solubility, stability, pharmacokinetics, biodistribution, and the ways of release and action between macromolecular proteins and small-molecule drugs. To improve the efficacy and safety of tumor treatment, people are committed to developing protein and drug co-delivery systems. Currently, intracellular co-delivery systems have been developed that integrate proteins and small-molecule drugs into one nanocarrier via various loading strategies. These systems significantly improve the blood stability, half-life, and biodistribution of proteins and small-molecule drugs, thus increasing their concentration in tumors. Furthermore, proteins and small-molecule drugs within these systems can be specifically targeted to tumor cells, and are released to perform functions after entering tumor cells simultaneously, resulting in improved effectiveness and safety of tumor treatment. This review summarizes the latest progress in protein and small-molecule drug intracellular co-delivery systems, with emphasis on the composition of nanocarriers, as well as on the loading methods of proteins and small-molecule drugs that play a role in cells into the systems, which have not been summarized by others so far. |
| first_indexed | 2024-12-10T15:00:41Z |
| format | Article |
| id | doaj.art-6cbf0bc65b004139ac53039b0b1e3d05 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T15:00:41Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-6cbf0bc65b004139ac53039b0b1e3d052022-12-22T01:44:10ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.994655994655Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapyZhihong Cheng0Zhihong Cheng1Yongshuang Li2Duoyi Zhao3Wei Zhao4Meng Wu5Weilin Zhang6Yan Cui7Peng Zhang8Zhiyu Zhang9Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, ChinaDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaIn the past few decades, the combination of proteins and small-molecule drugs has made tremendous progress in cancer treatment, but it is still not satisfactory. Because there are great differences in molecular weight, water solubility, stability, pharmacokinetics, biodistribution, and the ways of release and action between macromolecular proteins and small-molecule drugs. To improve the efficacy and safety of tumor treatment, people are committed to developing protein and drug co-delivery systems. Currently, intracellular co-delivery systems have been developed that integrate proteins and small-molecule drugs into one nanocarrier via various loading strategies. These systems significantly improve the blood stability, half-life, and biodistribution of proteins and small-molecule drugs, thus increasing their concentration in tumors. Furthermore, proteins and small-molecule drugs within these systems can be specifically targeted to tumor cells, and are released to perform functions after entering tumor cells simultaneously, resulting in improved effectiveness and safety of tumor treatment. This review summarizes the latest progress in protein and small-molecule drug intracellular co-delivery systems, with emphasis on the composition of nanocarriers, as well as on the loading methods of proteins and small-molecule drugs that play a role in cells into the systems, which have not been summarized by others so far.https://www.frontiersin.org/articles/10.3389/fbioe.2022.994655/fullnanocarriersproteinssmall-molecule drugsintracellular co-deliverycancer therapy |
| spellingShingle | Zhihong Cheng Zhihong Cheng Yongshuang Li Duoyi Zhao Wei Zhao Meng Wu Weilin Zhang Yan Cui Peng Zhang Zhiyu Zhang Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy Frontiers in Bioengineering and Biotechnology nanocarriers proteins small-molecule drugs intracellular co-delivery cancer therapy |
| title | Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy |
| title_full | Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy |
| title_fullStr | Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy |
| title_full_unstemmed | Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy |
| title_short | Nanocarriers for intracellular co-delivery of proteins and small-molecule drugs for cancer therapy |
| title_sort | nanocarriers for intracellular co delivery of proteins and small molecule drugs for cancer therapy |
| topic | nanocarriers proteins small-molecule drugs intracellular co-delivery cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.994655/full |
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