Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain
The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=4;spage=701;epage=704;aulast= |
| _version_ | 1818727694821490688 |
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| author | Joel F Ritala Seán B Lyne Antti Sajanti Romuald Girard Janne Koskimäki |
| author_facet | Joel F Ritala Seán B Lyne Antti Sajanti Romuald Girard Janne Koskimäki |
| author_sort | Joel F Ritala |
| collection | DOAJ |
| description | The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75NTR) in various injuries and diseases such as central nervous system injuries, Alzheimer’s disease and amyotrophic lateral sclerosis. More comprehensive elucidation of the mechanisms, and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury. Due to a diverse role of the p75NTR in biology, the body of evidence comprising its biological role is diffusely spread out over numerous fields. This review condenses the main evidence of p75NTR for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level. |
| first_indexed | 2024-12-17T22:18:11Z |
| format | Article |
| id | doaj.art-6cbf3a2102f24cf39f6f8b4320522b5d |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-17T22:18:11Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-6cbf3a2102f24cf39f6f8b4320522b5d2022-12-21T21:30:34ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-0117470170410.4103/1673-5374.314291Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brainJoel F RitalaSeán B LyneAntti SajantiRomuald GirardJanne KoskimäkiThe role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses, modify the response to injury, and alter the adaptation response. Intriguingly, the prior studies highlight the role of p75 neurotrophin receptor (p75NTR) in various injuries and diseases such as central nervous system injuries, Alzheimer’s disease and amyotrophic lateral sclerosis. More comprehensive elucidation of the mechanisms, and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury. Due to a diverse role of the p75NTR in biology, the body of evidence comprising its biological role is diffusely spread out over numerous fields. This review condenses the main evidence of p75NTR for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=4;spage=701;epage=704;aulast=bioinformatics; brain injury; data mining; neuron; neurotrophins; p75ntr; plasticity; regeneration |
| spellingShingle | Joel F Ritala Seán B Lyne Antti Sajanti Romuald Girard Janne Koskimäki Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain Neural Regeneration Research bioinformatics; brain injury; data mining; neuron; neurotrophins; p75ntr; plasticity; regeneration |
| title | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain |
| title_full | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain |
| title_fullStr | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain |
| title_full_unstemmed | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain |
| title_short | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain |
| title_sort | towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain |
| topic | bioinformatics; brain injury; data mining; neuron; neurotrophins; p75ntr; plasticity; regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=4;spage=701;epage=704;aulast= |
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