Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial
Background: Insulin receptor substrate (IRS) Type 1 is a main substrate for the insulin receptor, controls insulin signaling in skeletal muscle, adipose tissue, and the vascular, so it is an important candidate gene for insulin resistance (IR). We aimed to compare the effects of the Dietary Approach...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=9;spage=832;epage=837;aulast=Kafeshani |
| _version_ | 1819116903572963328 |
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| author | Marzieh Kafeshani Mohsen Janghorbani Rasol Salehi Mohammad Kazemi Mohammad Hasan Entezari |
| author_facet | Marzieh Kafeshani Mohsen Janghorbani Rasol Salehi Mohammad Kazemi Mohammad Hasan Entezari |
| author_sort | Marzieh Kafeshani |
| collection | DOAJ |
| description | Background: Insulin receptor substrate (IRS) Type 1 is a main substrate for the insulin receptor, controls insulin signaling in skeletal muscle, adipose tissue, and the vascular, so it is an important candidate gene for insulin resistance (IR). We aimed to compare the effects of the Dietary Approaches to Stop Hypertension (DASH) and Usual Dietary Advices (UDA) on IRS1 gene expression in women at risk for cardiovascular disease. Materials and Methods: A randomized controlled clinical trial was performed in 44 women at risk for cardiovascular disease. Participants were randomly assigned to a UDA diet or the DASH diet. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, cholesterol, refined grains, and sweets, with a total of 2400 mg/day sodium. The UDA diet was a regular diet with healthy dietary advice. Gene expression was assessed by the real-time polymerase chain reaction at the first of study and after 12 weeks. Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively. Results: IRS1 gene expression was increased in DASH group compared with UDA diet (P = 0.00). Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference. Conclusion: DASH diet increased IRS1 gene expression and probably has beneficial effects on IR risks. |
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| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-22T05:24:29Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-6cc09f9934b144859f19ed8e9cd716c42022-12-21T18:37:37ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362015-01-0120983283710.4103/1735-1995.170596Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trialMarzieh KafeshaniMohsen JanghorbaniRasol SalehiMohammad KazemiMohammad Hasan EntezariBackground: Insulin receptor substrate (IRS) Type 1 is a main substrate for the insulin receptor, controls insulin signaling in skeletal muscle, adipose tissue, and the vascular, so it is an important candidate gene for insulin resistance (IR). We aimed to compare the effects of the Dietary Approaches to Stop Hypertension (DASH) and Usual Dietary Advices (UDA) on IRS1 gene expression in women at risk for cardiovascular disease. Materials and Methods: A randomized controlled clinical trial was performed in 44 women at risk for cardiovascular disease. Participants were randomly assigned to a UDA diet or the DASH diet. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fat, total fat, cholesterol, refined grains, and sweets, with a total of 2400 mg/day sodium. The UDA diet was a regular diet with healthy dietary advice. Gene expression was assessed by the real-time polymerase chain reaction at the first of study and after 12 weeks. Independent sample t-test and paired-samples t-test were used to compare means of all variables within and between two groups respectively. Results: IRS1 gene expression was increased in DASH group compared with UDA diet (P = 0.00). Weight and waist circumference decreased in DASH group significantly compared to the UDA group (P < 0.05) but the results between the two groups showed no significant difference. Conclusion: DASH diet increased IRS1 gene expression and probably has beneficial effects on IR risks.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=9;spage=832;epage=837;aulast=KafeshaniDietDietary Approaches to Stop Hypertension dietinsulin receptor substrate 1gene expressioninsulin resistance |
| spellingShingle | Marzieh Kafeshani Mohsen Janghorbani Rasol Salehi Mohammad Kazemi Mohammad Hasan Entezari Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial Journal of Research in Medical Sciences Diet Dietary Approaches to Stop Hypertension diet insulin receptor substrate 1gene expression insulin resistance |
| title | Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial |
| title_full | Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial |
| title_fullStr | Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial |
| title_full_unstemmed | Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial |
| title_short | Dietary approaches to stop hypertension influence on insulin receptor substrate-1gene expression: A randomized controlled clinical trial |
| title_sort | dietary approaches to stop hypertension influence on insulin receptor substrate 1gene expression a randomized controlled clinical trial |
| topic | Diet Dietary Approaches to Stop Hypertension diet insulin receptor substrate 1gene expression insulin resistance |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=9;spage=832;epage=837;aulast=Kafeshani |
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