Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental
Objective: the alteration of hormones regulating sodium and water status is related to renal failure in obstructive jaundice (OJ). Experimental design: OJ was induced by common bile duct ligation. Samples were obtained from the control (SO) and OJ groups at 24 and 72 hours, and at 7 days. Different...
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| Format: | Article |
| Language: | English |
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Aran Ediciones
2009-06-01
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| Series: | Revista Espanola de Enfermedades Digestivas |
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| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009000600006 |
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| author | F. J Padillo A Cruz I Espejo M Barcos M Gómez-Álvarez J Muntané |
| author_facet | F. J Padillo A Cruz I Espejo M Barcos M Gómez-Álvarez J Muntané |
| author_sort | F. J Padillo |
| collection | DOAJ |
| description | Objective: the alteration of hormones regulating sodium and water status is related to renal failure in obstructive jaundice (OJ). Experimental design: OJ was induced by common bile duct ligation. Samples were obtained from the control (SO) and OJ groups at 24 and 72 hours, and at 7 days. Different parameters related to biliary obstruction, liver and renal injury, and vasoactive mediators such as renin, aldosterone, endothelin-1 (ET-1) and prostaglandin E2 (PGE2) were studied. Results: bile duct ligation caused an increase in total bilirubin (p < 0.001) and alkaline phosphatase (AP) (p < 0.001). The SO and OJ groups had the same values for diuresis, renin, and creatinine clearance at 24 h. However, animals with OJ had a lower sodium concentration in urine than SO animals (p < 0.01), as well as an increase in aldosterone levels (p < 0.03). ANP levels were moderately increased during OJ but did not reach statistical significance when compared to the SO group. In contrast, OJ animals showed a rise in serum ET-1 concentration (p < 0.001) and increased PGE2 in urine (p < 0.001). Conclusions: biliary obstruction induced an increase in ET-1 release and PGE2 urine excretion. These hormones might play a role during the renal complications associated with renal disturbances that occur during OJ. |
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| format | Article |
| id | doaj.art-6cc0ead7d89340cc9410323a1555c1d6 |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-12-23T13:31:00Z |
| publishDate | 2009-06-01 |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-6cc0ead7d89340cc9410323a1555c1d62022-12-21T17:45:09ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082009-06-011016408412Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimentalF. J PadilloA CruzI EspejoM BarcosM Gómez-ÁlvarezJ MuntanéObjective: the alteration of hormones regulating sodium and water status is related to renal failure in obstructive jaundice (OJ). Experimental design: OJ was induced by common bile duct ligation. Samples were obtained from the control (SO) and OJ groups at 24 and 72 hours, and at 7 days. Different parameters related to biliary obstruction, liver and renal injury, and vasoactive mediators such as renin, aldosterone, endothelin-1 (ET-1) and prostaglandin E2 (PGE2) were studied. Results: bile duct ligation caused an increase in total bilirubin (p < 0.001) and alkaline phosphatase (AP) (p < 0.001). The SO and OJ groups had the same values for diuresis, renin, and creatinine clearance at 24 h. However, animals with OJ had a lower sodium concentration in urine than SO animals (p < 0.01), as well as an increase in aldosterone levels (p < 0.03). ANP levels were moderately increased during OJ but did not reach statistical significance when compared to the SO group. In contrast, OJ animals showed a rise in serum ET-1 concentration (p < 0.001) and increased PGE2 in urine (p < 0.001). Conclusions: biliary obstruction induced an increase in ET-1 release and PGE2 urine excretion. These hormones might play a role during the renal complications associated with renal disturbances that occur during OJ.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009000600006AldosteroneCreatinineEndothelin-1Obstructive jaundiceRenal dysfunctionRenin |
| spellingShingle | F. J Padillo A Cruz I Espejo M Barcos M Gómez-Álvarez J Muntané Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental Revista Espanola de Enfermedades Digestivas Aldosterone Creatinine Endothelin-1 Obstructive jaundice Renal dysfunction Renin |
| title | Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental |
| title_full | Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental |
| title_fullStr | Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental |
| title_full_unstemmed | Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental |
| title_short | Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice Alteración del patrón hormonal regulatorio renal durante la ictericia obstructiva experimental |
| title_sort | alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice alteracion del patron hormonal regulatorio renal durante la ictericia obstructiva experimental |
| topic | Aldosterone Creatinine Endothelin-1 Obstructive jaundice Renal dysfunction Renin |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009000600006 |
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