Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer
Breast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may furt...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Sports |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4663/8/6/80 |
| _version_ | 1797566500581670912 |
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| author | Gabriel H. Zieff Chad W. Wagoner Craig Paterson Patricia Pagan Lassalle Jordan T. Lee |
| author_facet | Gabriel H. Zieff Chad W. Wagoner Craig Paterson Patricia Pagan Lassalle Jordan T. Lee |
| author_sort | Gabriel H. Zieff |
| collection | DOAJ |
| description | Breast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may further contribute to cardiovascular disease risk in this population by limiting the ability to engage in aerobic exercise—a known promoter of cardiovascular health. Indeed, 20–30% decreases in peak oxygen consumption are commonly observed in breast cancer survivors, which are indicative of exercise intolerance. Thus, breast-cancer-related skeletal muscle damage may reduce exercise-based opportunities for cardiovascular disease risk reduction. Resistance training is a potential strategy to improve skeletal muscle health in this population, which in turn may enhance the capacity to engage in aerobic exercise and reduce cardiovascular disease risk. |
| first_indexed | 2024-03-10T19:28:43Z |
| format | Article |
| id | doaj.art-6cc1e7fc9a4249afa5b0e33cb789e2cf |
| institution | Directory Open Access Journal |
| issn | 2075-4663 |
| language | English |
| last_indexed | 2024-03-10T19:28:43Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sports |
| spelling | doaj.art-6cc1e7fc9a4249afa5b0e33cb789e2cf2023-11-20T02:21:54ZengMDPI AGSports2075-46632020-05-01868010.3390/sports8060080Cardiovascular Consequences of Skeletal Muscle Impairments in Breast CancerGabriel H. Zieff0Chad W. Wagoner1Craig Paterson2Patricia Pagan Lassalle3Jordan T. Lee4Exercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700, USAExercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700, USASchool of Sport and Exercise, University of Gloucestershire, Cheltenham GL2 9HW, UKExercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700, USAExercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700, USABreast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may further contribute to cardiovascular disease risk in this population by limiting the ability to engage in aerobic exercise—a known promoter of cardiovascular health. Indeed, 20–30% decreases in peak oxygen consumption are commonly observed in breast cancer survivors, which are indicative of exercise intolerance. Thus, breast-cancer-related skeletal muscle damage may reduce exercise-based opportunities for cardiovascular disease risk reduction. Resistance training is a potential strategy to improve skeletal muscle health in this population, which in turn may enhance the capacity to engage in aerobic exercise and reduce cardiovascular disease risk.https://www.mdpi.com/2075-4663/8/6/80skeletal musclebreast canceraerobic exerciseresistance training |
| spellingShingle | Gabriel H. Zieff Chad W. Wagoner Craig Paterson Patricia Pagan Lassalle Jordan T. Lee Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer Sports skeletal muscle breast cancer aerobic exercise resistance training |
| title | Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer |
| title_full | Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer |
| title_fullStr | Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer |
| title_full_unstemmed | Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer |
| title_short | Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer |
| title_sort | cardiovascular consequences of skeletal muscle impairments in breast cancer |
| topic | skeletal muscle breast cancer aerobic exercise resistance training |
| url | https://www.mdpi.com/2075-4663/8/6/80 |
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